Recent Advances in Discovery, Biosynthesis and Genome Mining of Medicinally Relevant Polycyclic Tetramate Macrolactams
文献类型：期刊论文
| 作者 | Zhang, Guangtao; Zhang, Wenjun; Saha, Subhasish; Zhang, Changsheng |
| 刊名 | CURRENT TOPICS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2016 |
| 卷号 | 16期号:15页码:1727-1739 |
| 关键词 | Bioactivity Biosynthesis Cyclization Genome mining Natural products Polycyclic tetramate macrolactams |
| 通讯作者 | Zhang, CS (reprint author), Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China. |
| 中文摘要 | Polycyclic tetramate macrolactams (PTMs), a widely distributed class of structurally complex natural products exhibiting diverse biological activities, share a tetramate-containing macrocyclic lactam ring fused to a subset of carbocyclic rings. More than 30 naturally occurring PTM members have been reported Representative members include ikarugamycin, HSAF, and alteramides. The emerging significance of PTMs in medicinal applications has raised attentions on their biosynthetic studies. These studies have unveiled the unexpected conservation of compact PTM biosynthetic loci in phylogenetically diverse bacteria and elucidated mechanisms for key steps in PTM biosynthesis. PTMs were demonstrated to be derived from the common origin of a hybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) pathway, in which the PKS portion was iteratively used to generate two separate polyketide chains. A common tetramate-containing polyene intermediate was proposed to be the final product of all PTM PKS/NRPS assembly lines. Subsequently, a set of oxidoreductases acted in a not yet clearly understood way to dictate the manner of cyclizations to yield different polycycle ring systems in PTMs. The only well studied example was the formation of the inner five-membered ring in ikarugamycin, which was catalyzed by an alcohol dehydrogenase via a [1 + 6] Michael addition. Nonetheless, these studies have illustrated the extraordinary simplicity of nature's art in the biosynthesis of PTMs with complex structures and paved the way to further expand the structural diversity of the family of medicinally relevant PTMs by genome mining and combinatorial biosynthesis. |
| 学科主题 | Pharmacology & Pharmacy |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/15526]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Guangtao,Zhang, Wenjun,Saha, Subhasish,et al. Recent Advances in Discovery, Biosynthesis and Genome Mining of Medicinally Relevant Polycyclic Tetramate Macrolactams[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2016,16(15):1727-1739. |
| APA | Zhang, Guangtao,Zhang, Wenjun,Saha, Subhasish,&Zhang, Changsheng.(2016).Recent Advances in Discovery, Biosynthesis and Genome Mining of Medicinally Relevant Polycyclic Tetramate Macrolactams.CURRENT TOPICS IN MEDICINAL CHEMISTRY,16(15),1727-1739. |
| MLA | Zhang, Guangtao,et al."Recent Advances in Discovery, Biosynthesis and Genome Mining of Medicinally Relevant Polycyclic Tetramate Macrolactams".CURRENT TOPICS IN MEDICINAL CHEMISTRY 16.15(2016):1727-1739. |
入库方式： OAI收割
来源：南海海洋研究所
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