Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702
文献类型：期刊论文
| 作者 | Wang, Junfeng; Wei, Xiaoyi; Qin, Xiaochu; Tian, Xinpeng; Liao, Li; Li, Kemin; Zhou, Xuefeng; Yang, Xianwen; Wang, Fazuo; Zhang, Tianyu |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2016 |
| 卷号 | 79期号:1页码:59-65 |
| 通讯作者 | Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China. |
| 中文摘要 | Five new highly oxygenated alpha-pyrone merosesquiterpenoids, ochraceopones A-E (1-5), together with one new double bond isomer of asteltoxin, isoasteltoxin (6), and two known asteltoxin derivatives, asteltoxin (7) and asteltoxin B (8), were isolated from an Antarctic soil-derived fungus, Aspergillus ochraceopetaliformis SCSIO 05702. Their structures were determined through extensive spectroscopic analysis, CD spectra, quantum mechanical calculations, and X-ray single-crystal diffraction. Ochraceopones A-D (1-4) are the first examples of alpha-pyrone merosesquiterpenoids possessing a linear tetracyclic carbon skeleton, which has not been previously described. All the isolated compounds were tested for their antiviral, cytotoxic, antibacterial, and antitubercular activities. Among these compounds, ochraceopone A (1), isoasteltoxin (6), and asteltoxin (7) exhibited antiviral activities against the H1N1 and H3N2 influenza viruses with IC50 values of >20.0/12.2 +/- 4.10, 0.23 +/- 0.05/0.66 +/- 0.09, and 0.54 +/- 0.06/0.84 +/- 0.02 mu M, respectively. A possible biosynthetic pathway for ochraceopones A-E (1-5) was proposed. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/15534]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Junfeng,Wei, Xiaoyi,Qin, Xiaochu,et al. Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(1):59-65. |
| APA | Wang, Junfeng.,Wei, Xiaoyi.,Qin, Xiaochu.,Tian, Xinpeng.,Liao, Li.,...&Liu, Yonghong.(2016).Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702.JOURNAL OF NATURAL PRODUCTS,79(1),59-65. |
| MLA | Wang, Junfeng,et al."Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702".JOURNAL OF NATURAL PRODUCTS 79.1(2016):59-65. |
入库方式： OAI收割
来源：南海海洋研究所
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