Two isoforms of leptin in the White-clouds Mountain minnow (Tanichthys albonubes): Differential regulation by estrogen despite similar response to fasting
文献类型：期刊论文
| 作者 | Chen, Ting; Chen, Shuang; Ren, Chunhua; Hu, Chaoqun; Tang, Dongsheng; Yan, Aifen |
| 刊名 | GENERAL AND COMPARATIVE ENDOCRINOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 225页码:174-184 |
| 关键词 | Leptin Cyprinid fish Molecular cloning Fasting Estrogen Gene expression |
| 通讯作者 | Yan, AF (reprint author), Foshan Univ, Coll Med, Foshan, Peoples R China. |
| 中文摘要 | Leptin has been well-established as a canonical anorexic peptide hormone in mammals, though much of its function in fish remains obscure. In this study, the cDNAs of two leptin isoforms (leptin-A and leptin-B) were cloned from the liver of a small cyprinid fish, Tanichthys albonubes. The two T. albonubes leptins, sharing low primary amino acid sequence homology with their mammalian counterparts, and between themselves, are highly conserved in three-dimensional protein structures and gene structures. Liver is a major source of leptin mRNA in T. albonubes with leptin-A being the dominant form. The expression of hepatic leptin-A but not leptin-B mRNA in female fish is significantly higher than in male fish. Transcriptional hepatic levels of leptin-A and leptin-B in both male and female fish were demonstrated to increase after long-term fasting (10-25 days) but decline upon re-feeding (3 days). Strikingly, estrogen (E-2) administration induced only leptin-A but not leptin-B hepatic mRNA expression in both male and female fish. Our study here provides the first evidence for differential regulation of two leptins in fish, and sheds new light on the possible origin of leptin in lower vertebrates. (C) 2015 Elsevier Inc. All rights reserved. |
| 学科主题 | Endocrinology & Metabolism |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/15536]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Ting,Chen, Shuang,Ren, Chunhua,et al. Two isoforms of leptin in the White-clouds Mountain minnow (Tanichthys albonubes): Differential regulation by estrogen despite similar response to fasting[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2016,225:174-184. |
| APA | Chen, Ting,Chen, Shuang,Ren, Chunhua,Hu, Chaoqun,Tang, Dongsheng,&Yan, Aifen.(2016).Two isoforms of leptin in the White-clouds Mountain minnow (Tanichthys albonubes): Differential regulation by estrogen despite similar response to fasting.GENERAL AND COMPARATIVE ENDOCRINOLOGY,225,174-184. |
| MLA | Chen, Ting,et al."Two isoforms of leptin in the White-clouds Mountain minnow (Tanichthys albonubes): Differential regulation by estrogen despite similar response to fasting".GENERAL AND COMPARATIVE ENDOCRINOLOGY 225(2016):174-184. |
入库方式： OAI收割
来源：南海海洋研究所
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