己烯雌酚及代谢物在鲫鱼体内的组织分布及药物代谢动力学
文献类型：期刊论文
| 作者 | 田秀慧; 薛敬林; 邓旭修; 徐英江; 宫向红; 夏传海
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| 刊名 | 中国食品学报
 |
| 出版日期 | 2015-11-30 |
| 卷号 | 15期号:11页码:178-185 |
| 关键词 | 己烯雌酚 双烯雌酚 鲫鱼 药物代谢动力学 超高效液相色谱-串联质谱法 |
| ISSN号 | 1009-7848 |
| 其他题名 | Tissue Distribution and Pharmacokinetics of Diethylstilbestrol and Its Metabolite Dienestrol in Carassius auratus |
| 产权排序 | 中国科学院烟台海岸带研究所;山东省海洋资源与环境研究院;中国科学院大学; |
| 中文摘要 | 为全面了解己烯雌酚在鲫鱼体内的残留、消除和药物动力学特征,采用超高效液相色谱-串联质谱法,研究口服灌药给药时己烯雌酚及其主要代谢物双烯雌酚在鲫鱼体内的组织分布和药物代谢动力学。在水温(12±2)℃条件下,鲫鱼口服灌药0.1,1.0 mg/(kg bw)和10.0 mg/(kg bw)后,其血浆、肌肉和肝脏中己烯雌酚浓度-时间曲线关系符合一级吸收的二室开放动力学模型。以剂量1.0 mg/(kg bw)为例,3种组织中己烯雌酚峰值水平肝脏最高,肌肉次之,血浆最低,己烯雌酚的平均消除速率均较快,分别为26.7μg/(L·h),3.75μg/(kg·h)和9.26μg/(kg·h),在12,144 h... |
| 英文摘要 | Tissue distribution and pharmacokinetics of Diethylstilbestrol and its metabolite Dienestrol in plasma,muscle and liver of Carassius auratus under laboratory conditions using single oral administration was studied by ultra performance liquid chromatogram tandem mass spectrometry in this work. After administration by single oral of 0.1, 1.0mg/(kg bw) and 10.0 mg/(kg bw), Diethylstilbestrol concentrations in plasma, muscle and liver versus time were well described by a two-department open model with first-order absorption. For example, after single oral of 1.0 mg/(kg bw),the biggest concentration of Diethylstilbestrol in liver was highest, the next was muscle and the lowest was plasma. The average elimination speed was 26.7 μg/(L·h), 3.75 μg/(kg·h) and 9.26 μg/(kg·h) of plasma, muscle and liver, showing that Diethylstilbestrol could eliminate fast in Carassius auratus. Diethylstilbestrol was no detected after oral administration of 12 h, 144 h and 144 h. The variation of Dienestrol concentrations in plasma, muscle and liver of Carassius auratus was similar with Diethylstilbestrol, first increased and then decreased. Concentrations of Dienestrol in plasma, muscle and liver could reach peak after oral administration of 3, 10 h and 8 h, and no detected after 12, 144 h and 144 h. DAS2.0 pharmacokinetic parameter calculation program was used to process Diethylstilbestrol content-time datas and to calculate the relevant pharmacokinetic parameters of Diethylstilbestrol. For example, in the concentration of 1.0 mg/(kg bw),the results indicated that area under concentration-time curve(AUC) differed greatly in plasma, muscle and liver of Carassius auratus and the tissues had different accumulation capability. The overall clearance rate of Diethylstilbestrol in plasma, muscle and liver was 1.041, 0.121 L/(h·kg) and 0.052 L/(h·kg), indicating distribution was dispersed and elimination was fast. Under the experimental conditions, when Carassius auratus using single oral administration of0.1, 1.0 mg/(kg bw) and 10.0 mg/(kg bw), it was recommended withdrawal period of 4, 6 d and 7 d respectively. When the water temperature was highter than the experimental conditions, the withdrawal period could be shorten; and extended in lower water temperature. The concentrations versus time curves of Diethylstilbestrol in Carassius auratus provided useful information for studying decontamination of Carassius auratus that had Diethylstilbestrol contamination. |
| 收录类别 | CSCD |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5586878 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/17261]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.中国科学院烟台海岸带研究所 2.山东省海洋资源与环境研究院 3.中国科学院大学 |
| 推荐引用方式 GB/T 7714 | 田秀慧,薛敬林,邓旭修,等. 己烯雌酚及代谢物在鲫鱼体内的组织分布及药物代谢动力学[J]. 中国食品学报,2015,15(11):178-185. |
| APA | 田秀慧,薛敬林,邓旭修,徐英江,宫向红,&夏传海.(2015).己烯雌酚及代谢物在鲫鱼体内的组织分布及药物代谢动力学.中国食品学报,15(11),178-185. |
| MLA | 田秀慧,et al."己烯雌酚及代谢物在鲫鱼体内的组织分布及药物代谢动力学".中国食品学报 15.11(2015):178-185. |
入库方式： OAI收割
来源：烟台海岸带研究所
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