High Morphologic Plasticity of Microglia/Macrophages Following Experimental Intracerebral Hemorrhage in Rats
文献类型：期刊论文
| 作者 | Yang, Shu-Sheng1,2,3; Lin, Li1,2,4; Liu, Yue5,6; Wang, Jie6; Chu, Jiang1,2; Zhang, Teng1,2; Ning, Lin-Na1,2; Shi, Yan1,2; Fang, Ying-Yan1,2; Zeng, Peng1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 17期号:7 |
| 关键词 | microglia intracerebral hemorrhage interleukin-1 interleukin-10 |
| 英文摘要 | As current efforts have limited effects on the clinical outcome of intracerebral hemorrhage (ICH), the mechanisms including microglia/macrophages that involved inflammation need further investigation. Here, 0.4 units of collagenase VII were injected into the left caudate putamen (CPu) to duplicate ICH rat models. In the brains of ICH rats, microglia/macrophages, the nearest cells to the hemorrhagic center, were observed as ameboid and Prussian-blue positive. Furthermore, the ameboid microglia/macrophages were differentiation (CD) 68 and interleukin-1 (IL-1) positive, and neither CD206 nor chitinase3-like 3 (Ym1) positive, suggesting their strong abilities of phagocytosis and secretion of IL-1. According to the distance to the hemorrhagic center, we selected four areasI, II, III, and IVto analyze the morphology of microglia/macrophages. The processes decreased successively from region I to region IV. Microglia/macrophages in region IV had no processes. The processes in region I were radially distributed, however, they showed obvious directivity towards the hemorrhagic center in regions II and III. Region III had the largest density of compactly arrayed microglia/macrophages. All these in vivo results present the high morphologic plasticity of microglia/macrophages and their functions in the pathogenesis of ICHs. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | BRAIN-INJURY ; MICROGLIA ; MACROPHAGES ; POLARIZATION ; INFLAMMATION ; COLLAGENASE ; ACTIVATION ; MODELS ; STROKE ; BLOOD |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000381500900190 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9588]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Pathol & Pathophysiol, Sch Basic Med, Hangkong Rd 13, Wuhan 430030, Peoples R China 2.Huazhong Univ Sci & Technol, Inst Brain Res, Hangkong Rd 13, Wuhan 430030, Peoples R China 3.Hubei Univ Tradit Chinese Med, Clin Coll Tradit Chinese Med, Dept Shang Han, Tan Hua Lin Rd 1, Wuhan 430061, Peoples R China 4.Hubei Univ Tradit Chinese Med, Sch Basic Med, Lab Med Mol & Cellular Biol, Wuhan 430065, Peoples R China 5.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 6.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Shu-Sheng,Lin, Li,Liu, Yue,et al. High Morphologic Plasticity of Microglia/Macrophages Following Experimental Intracerebral Hemorrhage in Rats[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(7). |
| APA | Yang, Shu-Sheng.,Lin, Li.,Liu, Yue.,Wang, Jie.,Chu, Jiang.,...&Tian, Qing.(2016).High Morphologic Plasticity of Microglia/Macrophages Following Experimental Intracerebral Hemorrhage in Rats.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(7). |
| MLA | Yang, Shu-Sheng,et al."High Morphologic Plasticity of Microglia/Macrophages Following Experimental Intracerebral Hemorrhage in Rats".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17.7(2016). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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