Polymorphs of acyclovir-maleic acid salt and their reversible phase transition
文献类型：期刊论文
| 作者 | Wang, Lianyan1; Zhao, Yumei2; Zhang, Zhengfeng3; Wang, Jianming4; Wang, Qiang3; Zheng, Zhibing2; Deng, Zongwu1; Zhang, Hailu1 |
| 刊名 | JOURNAL OF MOLECULAR STRUCTURE
 |
| 出版日期 | 2017-01-05 |
| 卷号 | 1127页码:247-251 |
| 关键词 | Acyclovir-maleic acid salt Pharmaceutical salt Polymorphism Solid phase transformation Solid-state NMR |
| 英文摘要 | Acyclovir is a commonly used antiviral drug while its solubility is far from satisfied. It was reported that 1:1 acyclovir-maleic acid salt (ACV-MAL) possesses much higher maximum apparent solubility. In this contribution, a new crystal structure of ACV-MAL was solved at room temperature. This new crystal structure and previously reported structure at low temperature can transform to each other via a reversible solid phase transformation, which has been confirmed by single-crystal X-ray diffraction, solid state NMR and cycling differential scanning calorimetry tests. The phase change temperature is ca. 283-293 K (10-20 degrees C), which is slightly lower than room temperature (298 +/- 2 K/25 +/- 2 degrees C), but is in the. range of ambient temperature. This kind of near room temperature phase transformation is less concerned and tends to be neglected. This case report reminds that more attention should be paid to the polymorphism of pharmaceuticals at such temperature range due to its fundamental and practical significance. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SOLID-STATE ; COCRYSTAL ; SOLUBILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385901800028 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9601]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Lab Magnet Resonance Spect & Imaging, Suzhou 215123, Peoples R China 2.Beijing Inst Pharmacol & Toxicol, Lab Comp Aided Drug Design & Discovery, Beijing 100850, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 4.Crystal Pharmatech, Suzhou Ind Pk, Suzhou 215123, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lianyan,Zhao, Yumei,Zhang, Zhengfeng,et al. Polymorphs of acyclovir-maleic acid salt and their reversible phase transition[J]. JOURNAL OF MOLECULAR STRUCTURE,2017,1127:247-251. |
| APA | Wang, Lianyan.,Zhao, Yumei.,Zhang, Zhengfeng.,Wang, Jianming.,Wang, Qiang.,...&Zhang, Hailu.(2017).Polymorphs of acyclovir-maleic acid salt and their reversible phase transition.JOURNAL OF MOLECULAR STRUCTURE,1127,247-251. |
| MLA | Wang, Lianyan,et al."Polymorphs of acyclovir-maleic acid salt and their reversible phase transition".JOURNAL OF MOLECULAR STRUCTURE 1127(2017):247-251. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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