Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives
文献类型：期刊论文
| 作者 | Hu, Linfeng1,2; Meng, Xiangtao1; Xing, Ronge1 ; Liu, Song1; Chen, Xiaolin1; Qin, Yukun1; Yu, Huahua1; Li, Pengcheng1
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2016-09-15 |
| 卷号 | 26期号:18页码:4548-4551 |
| 关键词 | Chitosan 6-N-substituted chitosan Antibacterial activity Antifungal activity |
| 英文摘要 | Three novel 6-N-substituted chitosan derivatives were designed and synthesised and characterized by FTIR and NMR. The degree of substitution was calculated by elemental analysis results. The antimicrobial activities of the target compounds were evaluated by twofold serial broth dilution method and poisoned food technique. The antifungal activities of 6-aminoethylamino-6-deoxy chitosan (3), 6-butylamino-6deoxy chitosan (4) and 6-pyridyl-6-deoxy chitosan (5) were significantly increased against Rhizoctonia cerealis, Fusarium oxysporum and Botrytis cinerea, and the inhibition rate ranged from 22.48% to 63.56% at the concentration of 0.2 mg/mL. The compound 3 had better antibacterial activities than chitosan, and the minimum inhibition concentration of which ranged between 6.25 and 25 mg/L against gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Bacillus anthracis) and gram-negative bacteria (Escherichia coli, Salmonella typhi). The antibacterial activities of 6-N-substituted chitosan tended to increase with the increase of the number of -NH2 group. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000382263800031 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/135863]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 海洋研究所_海洋环境工程技术研究发展中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Linfeng,Meng, Xiangtao,Xing, Ronge,et al. Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(18):4548-4551. |
| APA | Hu, Linfeng.,Meng, Xiangtao.,Xing, Ronge.,Liu, Song.,Chen, Xiaolin.,...&Li, Pengcheng.(2016).Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(18),4548-4551. |
| MLA | Hu, Linfeng,et al."Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.18(2016):4548-4551. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。