Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos
文献类型：期刊论文
| 作者 | Dong, Wu1,2; Liu, Jie3; Wei, Lixin4; Yang Jingfeng1; Chernick, Melissa2; Hinton, David E.2 |
| 刊名 | peerj
 |
| 出版日期 | 2016-08-23 |
| 卷号 | 4 |
| 关键词 | MeHg HgCl2 alpha-HgS (Zhu Sha, cinnabar) beta-HgS (Zuotai) Medaka Developmental toxicity Heme oxygenase-1 Mercury Metallothionein |
| 英文摘要 | this study examined developmental toxicity of different mercury compounds eluding some used in traditional medicines. medaka (oryzias latipes) embryos were exposed to 0.001-10 mu m concentrations of mehg, hgcl2, alpha-hgs (zhu sha), and, beta-hgs (zuotai) from stage 10 (6-7 hpf) to 10 days post fertilization (dpf). of the forms of mercury in this study, the organic form (mehg) proved the most toxic followed by inorganic mercury (hgcl2), both producing embryo developmental toxicity. altered phenotypes included pericardial edema with elongated or tube heart, reduction of eye pigmentation, and failure of swim bladder inflation. both alpha-hgs and, beta-hgs were less toxic than mehg and hgcl2. total rna was extracted from survivors three days after exposure to mehg (0.1 mu m), hgcl2 (1 mu m), alpha-hgs (10 mu m), or beta-hgs (10 mu m) to examine toxicity-related gene expression. mehg and hgc12 markedly induced. metallothionein (mt) and heme oxygenase-1 (ho-1), while alpha-hgs and beta-hgs faded to induce either gene. chemical forms of mercury compounds proved to be a major determinant in their developmental toxicity. |
| WOS标题词 | science & technology |
| 类目[WOS] | multidisciplinary sciences |
| 研究领域[WOS] | science & technology - other topics |
| 关键词[WOS] | early-life stage ; metallothionein gene-expression ; proteomic analysis reveals ; heavy-metal ions ; niu-huang-wan ; japanese medaka ; methyl mercury ; danio-rerio ; zebrafish ; cadmium |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000383261200002 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/6452]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Inner Mongolia Univ Nationalities, Coll Anim Sci & Technol, Inner Molgolia Prov Key Lab Toxicants & Anim Dis, Tongliao, Peoples R China 2.Duke Univ, Nicholas Sch Environm, Durham, NC USA 3.Zunyi Med Coll, Dept Pharmacol, Zunyi, Peoples R China 4.Chinese Acad Sci, Northwest Inst Plateau Biol, Dept Tibetan Med, Xining, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Wu,Liu, Jie,Wei, Lixin,et al. Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos[J]. peerj,2016,4. |
| APA | Dong, Wu,Liu, Jie,Wei, Lixin,Yang Jingfeng,Chernick, Melissa,&Hinton, David E..(2016).Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos.peerj,4. |
| MLA | Dong, Wu,et al."Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos".peerj 4(2016). |
入库方式： OAI收割
来源：西北高原生物研究所
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