Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia
文献类型：期刊论文
| 作者 | Yang, Fang1,2,3; Suo, Yourui1,4; Chen, Dongli5; Tong, Li2 |
| 刊名 | bioscience trends
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 10期号:3页码:188-196 |
| 关键词 | Vascular endothelial dysfunction polyphenol sea buckthorn berries hyperlipidemia protection |
| 英文摘要 | chronic hyperlipemia increases the incidence of vascular endothelial dysfunction and can even induce cardiovascular disease. sea buckthorn contains a host of bioactives such as flavonoids and polyphenols that can prevent the development of cardiovascular disease. the current study isolated active ingredients, polyphenols, from sea buckthorn berries (svp) and orally administered svp at a dose of 7-28 mg/kg. this treatment significantly reduced serum lipids, it enhanced the activity of antioxidant enzymes, and it decreased the level of serum tnf-alpha and il-6. svp also alleviate vascular impairment by decreasing the expression of enos, icam-1, and lox-1 mrna and proteins in aortas of rats with hyperlipidemia. based on these findings, svp has antioxidant action and it protects endothelium. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biology |
| 研究领域[WOS] | life sciences & biomedicine - other topics |
| 关键词[WOS] | hippophae-rhamnoides l. ; low-density-lipoprotein ; coronary heart-disease ; nlrp3 inflammasome ; oxidative stress ; risk-factors ; in-vitro ; flavonoids ; antioxidant ; activation |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000379253700004 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/6469]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, 23 Xinning Rd, Xining 810001, Qinghai, Peoples R China 2.Qinghai Univ, Coll Med, Xining, Qinghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Qinghai Univ, Qinghai Acad Agr & Forestry Sci, Xining, Qinghai, Peoples R China 5.AA Pharma Inc, Boston, MA USA |
| 推荐引用方式 GB/T 7714 | Yang, Fang,Suo, Yourui,Chen, Dongli,et al. Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia[J]. bioscience trends,2016,10(3):188-196. |
| APA | Yang, Fang,Suo, Yourui,Chen, Dongli,&Tong, Li.(2016).Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia.bioscience trends,10(3),188-196. |
| MLA | Yang, Fang,et al."Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia".bioscience trends 10.3(2016):188-196. |
入库方式： OAI收割
来源：西北高原生物研究所
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