Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen-Cope rearrangement
文献类型：期刊论文
| 作者 | Mei, Qinggang; Wang, Chun; Zhao, Zhigang; Yuan, Weicheng; Zhang, Guolin |
| 刊名 | BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 11页码:1220-1225 |
| 关键词 | IN-VITRO FLAVONOIDS POTENT CELLS DIFFERENTIATION DERIVATIVES PRENYLATION PROMOTES |
| 产权排序 | 1 |
| 通讯作者 | Zhang, GL (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 合作状况 | 国内 |
| 英文摘要 | The hemisynthesis of the naturally occurring bioactive flavonoid glycoside icariin (1) has been accomplished in eleven steps with 7% overall yield from kaempferol. The 4'-OH methylation of kaempferol, the 8-prenylation of 3-O-methoxymethyl-4'-O-methyl-5-O-prenyl-7-O-benzylkaempferol (8) via para-Claisen-Cope rearrangement catalyzed by Eu(fod)(3) in the presence of NaHCO3, and the glycosylation of icaritin (3) are the key steps. |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Organic |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://210.75.237.14/handle/351003/27576]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Mei, Qinggang,Wang, Chun,Zhao, Zhigang,et al. Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen-Cope rearrangement[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2015,11:1220-1225. |
| APA | Mei, Qinggang,Wang, Chun,Zhao, Zhigang,Yuan, Weicheng,&Zhang, Guolin.(2015).Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen-Cope rearrangement.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,11,1220-1225. |
| MLA | Mei, Qinggang,et al."Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen-Cope rearrangement".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 11(2015):1220-1225. |
入库方式： OAI收割
来源：成都生物研究所
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