Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers
文献类型：期刊论文
| 作者 | Kang, Yang; Ma, Yuan; Zhang, Sheng; Ding, Li-Sheng; Li, Bang-Jing |
| 刊名 | ACS MACRO LETTERS
 |
| 出版日期 | 2015 |
| 卷号 | 4期号:5页码:543-547 |
| 关键词 | BLOCK-COPOLYMER MICELLES POLYMERIC MICELLES BETA-CYCLODEXTRIN ASSEMBLIES WATER NANOPARTICLES COMPLEXATION RECOGNITION NONCOVALENT TRANSITION |
| 产权排序 | 1 |
| 通讯作者 | Zhang, S (reprint author), Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China. |
| 合作状况 | 国内 |
| 英文摘要 | Two end-decorated homopolyrners, methoxy polyethylene glycol-ferrocene (mPEG-Fc) and poly(N-isopropylacrylamide)-beta-cyclodextrin (PNIPAM-beta-CD), were further orthogonally self-assembled into stable micelles in aqueous solution by controlling the temperature of the solution via terminal host-guest interactions. Because of the H2O2 cleavable CD/Fc connection and thermoresponsive PNIPAM, an H2O2 and thermo dual-controlled drug release based on this system was also achieved. Interestingly, the cytotoxicity evaluation of mPEG-Fc/PNIPAM-beta-CD indicated good biocompatibility. Compared with free doxorubicin, the doxorubicin-loaded supramolecular micelles exhibited equal cellular proliferation inhibition toward A549 cells. This supramolecular complex is thus anticipated to serve as a promising new type of alternative drug-delivery system. |
| 学科主题 | Polymer Science |
| 类目[WOS] | Polymer Science |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://210.75.237.14/handle/351003/27585]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Kang, Yang,Ma, Yuan,Zhang, Sheng,et al. Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers[J]. ACS MACRO LETTERS,2015,4(5):543-547. |
| APA | Kang, Yang,Ma, Yuan,Zhang, Sheng,Ding, Li-Sheng,&Li, Bang-Jing.(2015).Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers.ACS MACRO LETTERS,4(5),543-547. |
| MLA | Kang, Yang,et al."Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers".ACS MACRO LETTERS 4.5(2015):543-547. |
入库方式： OAI收割
来源：成都生物研究所
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