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Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles
文献类型：期刊论文
| 作者 | Zhao, Jian-Qiang; Zhou, Ming-Qiang; Wu, Zhi-Jun; Wang, Zhen-Hua; Yue, Deng-Feng; Xu, Xiao-Ying; Zhang, Xiao-Mei; Yuan, Wei-Cheng |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2015 |
| 卷号 | 17期号:9页码:2238-2241 |
| 关键词 | ORGANOCATALYTIC DOMINO REACTIONS MICHAEL-CYCLIZATION REACTION SELECTIVE 3+2 CYCLOADDITION HIGHLY EFFICIENT ISOTHIOCYANATO OXINDOLES SPIROCYCLIC OXINDOLES 1,3-DIPOLAR CYCLOADDITION NATURAL-PRODUCTS STEREOSELECTIVE CONSTRUCTION DIELS-ALDER |
| 通讯作者 | Yuan, WC (reprint author), Chinese Acad Sci, Chengdu Inst Organ Chem, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China. |
| 产权排序 | 2 |
| 合作状况 | 国内 |
| 英文摘要 | An unprecedented organocatalytic asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles and. 3-nitroindoles has-been disclosed. A wide range of enantioenriched polycyclic, spirooxindoles, containing three contiguous chiral centers With two of them having quaternary stereocenters, could be smoothly obtained with satisfactory results (up to 99%-yield, >99:1 dr, and 96% ee). This methods very promising because the reaction is scalable, and the versatile transformations of the products into other spirocyclic oxindoles are also feasible. |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Organic |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://210.75.237.14/handle/351003/27587]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Zhao, Jian-Qiang,Zhou, Ming-Qiang,Wu, Zhi-Jun,et al. Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles[J]. ORGANIC LETTERS,2015,17(9):2238-2241. |
| APA | Zhao, Jian-Qiang.,Zhou, Ming-Qiang.,Wu, Zhi-Jun.,Wang, Zhen-Hua.,Yue, Deng-Feng.,...&Yuan, Wei-Cheng.(2015).Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles.ORGANIC LETTERS,17(9),2238-2241. |
| MLA | Zhao, Jian-Qiang,et al."Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles".ORGANIC LETTERS 17.9(2015):2238-2241. |
入库方式： OAI收割
来源：成都生物研究所
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