Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers
文献类型：期刊论文
| 作者 | Zhang, Xiao-Mei; Guo, Kun; Li, Luo-Hao; Zhang, Sheng; Li, Bang-Jing |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:29页码:6026-6031 |
| 关键词 | AMPHIPHILIC TRIBLOCK COPOLYMERS IRON-OXIDE NANOPARTICLES GUIDED DRUG-DELIVERY POLYMERIC MICELLES GOLD NANOPARTICLE CANCER WATER VESICLES |
| 产权排序 | 1 |
| 通讯作者 | Sheng, ZB (reprint author), Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China. |
| 合作状况 | 国内 |
| 英文摘要 | A novel approach has been developed to prepare the magnetic micelles. Polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) are firstly attached on the surface of the magnetic nanoparticle via the host-guest inclusion between ferrocene groups (Fc) and beta-cyclodextrin (beta-CD). Then the resulting MNPs became amphiphilic in water above the LCST of PNIPAM and self-assembled into magnetomicelles with a size of 250 nm. These hybrid micelles show high loading capacity for anticancer drug (DOX) and high saturation magnetization simultaneously. Furthermore, these micelles could disassemble under the effects of oxidant or temperature, providing an opportunity to fine-tune the release properties of the encapsulated drug in response to temperature, H2O2 or pH independently, or a combined effect of multiple stimuli. Taking other advantages of magnetic carriers, such as high sensitivity to the external magnetic field, contrast effect to magnetic resonance, and magnetic hyperthermia, the micelles developed by this study show great potential application in cancer treatment. |
| 学科主题 | Materials Science |
| 类目[WOS] | Materials Science, Biomaterials |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://210.75.237.14/handle/351003/27601]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Zhang, Xiao-Mei,Guo, Kun,Li, Luo-Hao,et al. Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(29):6026-6031. |
| APA | Zhang, Xiao-Mei,Guo, Kun,Li, Luo-Hao,Zhang, Sheng,&Li, Bang-Jing.(2015).Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers.JOURNAL OF MATERIALS CHEMISTRY B,3(29),6026-6031. |
| MLA | Zhang, Xiao-Mei,et al."Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers".JOURNAL OF MATERIALS CHEMISTRY B 3.29(2015):6026-6031. |
入库方式： OAI收割
来源：成都生物研究所
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