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Alzheimer's disease and gut microbiota
文献类型：期刊论文
| 作者 | Hu, Xu ; Wang, Tao; Jin, Feng
|
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 59期号:10页码:1006-1023 |
| 关键词 | Alzheimer's disease gut microbiota leaky gut leaky brain diet infection hygiene hypothesis |
| ISSN号 | 1674-7305 |
| 英文摘要 | Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrier induced by gut microbiota disturbance will increase the incidence of neurodegeneration disorders. Gut microbial metabolites and their effects on host neurochemical changes may increase or decrease the risk of AD. Pathogenic microbes infection will also increase the risk of AD, and meanwhile, the onset of AD support the "hygiene hypothesis". All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for AD. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biology |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics |
| 关键词[WOS] | AMYOTROPHIC-LATERAL-SCLEROSIS ; SIMPLEX-VIRUS TYPE-1 ; BLOOD-BRAIN-BARRIER ; HELICOBACTER-PYLORI INFECTION ; MILD COGNITIVE IMPAIRMENT ; POPULATION-BASED CAIDE ; METHYLAMINO-L-ALANINE ; AMYLOID-BETA-PEPTIDE ; HYGIENE HYPOTHESIS ; CALORIC RESTRICTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385416200004 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20693]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xu,Wang, Tao,Jin, Feng. Alzheimer's disease and gut microbiota[J]. SCIENCE CHINA-LIFE SCIENCES,2016,59(10):1006-1023. |
| APA | Hu, Xu,Wang, Tao,&Jin, Feng.(2016).Alzheimer's disease and gut microbiota.SCIENCE CHINA-LIFE SCIENCES,59(10),1006-1023. |
| MLA | Hu, Xu,et al."Alzheimer's disease and gut microbiota".SCIENCE CHINA-LIFE SCIENCES 59.10(2016):1006-1023. |
入库方式： OAI收割
来源：心理研究所
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