The different effects of maternal separation on spatial learning and reversal learning in rats
文献类型：期刊论文
| 作者 | Wang, Qiong ; Li, Man; Du, Wei; Shao, Feng; Wang, Weiwen
|
| 刊名 | Behavioural Brain Research
 |
| 出版日期 | 2015 |
| 卷号 | 280期号:280页码:16-23 |
| 关键词 | Maternal separation Locomotor activity Anxiety Spatial learning Reversal learning |
| ISSN号 | 0166-4328 |
| 产权排序 | 2 |
| 通讯作者 | Shao, F |
| 英文摘要 | Early postnatal maternal separation (MS) can play an important role in the development of psychopathologies during ontogeny. In the present study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1 to 21) on locomotor activity and anxiety behavior in open field, spatial learning and reversal learning in Morris water maze of male and female juvenile (PND 21), adolescent (PND 35) and early adult (PND 56) Wistar rats. The results indicated that MS increased locomotor activity of rats across all ages and reduced anxiety behavior of adolescent rats in open field test. MS also increased swim distance in spatial learning and decreased escape latency in reversal learning in adolescent and early adult rats. Additionally, for socially reared rats, there was increased spontaneous locomotion with age, decreased reversal learning ability with age. The present study provides novel insights into the consequences of MS and demonstrates unique age-dependent changes at the behavioral levels. (C) 2014 Elsevier B.V. All rights reserved. |
| 学科主题 | 生理心理学/生物心理学 |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Natural Science Foundation of China (Grant No. 31470988), the National Natural Science Foundation of China (Grant No. 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. |
| 语种 | 英语 |
| WOS记录号 | WOS:000348255400003 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20741]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qiong,Li, Man,Du, Wei,et al. The different effects of maternal separation on spatial learning and reversal learning in rats[J]. Behavioural Brain Research,2015,280(280):16-23. |
| APA | Wang, Qiong,Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2015).The different effects of maternal separation on spatial learning and reversal learning in rats.Behavioural Brain Research,280(280),16-23. |
| MLA | Wang, Qiong,et al."The different effects of maternal separation on spatial learning and reversal learning in rats".Behavioural Brain Research 280.280(2015):16-23. |
入库方式： OAI收割
来源：心理研究所
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