Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems
文献类型：期刊论文
| 作者 | Guo, JY ; Wang, JY; Luo, F; Luo F
|
| 刊名 | Journal of Psychopharmacology
 |
| 出版日期 | 2010 |
| 卷号 | 24期号:10页码:1561-1567 |
| 通讯作者邮箱 | luof@psych.ac.cn |
| 关键词 | cue endogenous opioids mice morphine nonsteroid anti-inflammatory drugs placebo analgesia |
| ISSN号 | 1561-1567 |
| 产权排序 | 1 |
| 通讯作者 | Luo F |
| 英文摘要 | Amanzio and Benedetti (J Neurosci 1999; 19: 484-494) first addressed the conditions necessary for the activation of opioid and non-opioid placebo responses in human. Here, we investigated whether placebo analgesia is subdivided into opioid and non-opioid components in mice by using the model of hot-plate test. Drug conditioning was performed by the combination of the conditioned cue stimulus with the unconditioned drug stimulus, either opioid agonist morphine hydrochloride or non-opioid aspirin. Placebo analgesic responses were evoked by an exposure to a conditioned cue previously paired with drug conditioning. Morphine conditioning produced placebo responses that were completely antagonised by naloxone. By contrast, the conditioned cue after aspirin conditioning elicited a placebo effect that was not blocked by naloxone. Therefore, we first evoked opioid and non-opioid placebo responses in mice that were either naloxone-reversible or naloxone-insensitive, depending on the drug used in conditioning procedure. These findings support that the mechanisms underlying placebo analgesia may depend on the drug conditioning that was originally performed. The present procedure of mice may serve as a model for further understanding of the opioid and non-opioid mechanisms underlying placebo responses. |
| 学科主题 | 生理心理学/生物心理学 |
| 收录类别 | SCI |
| 项目简介 | This study was supported by NNSF grants (30570577 and 30770688), the 100 Talented Plan of the Chinese Academy of Sciences, and the 863 project (2006AA02Z431) of China to LF; a Director starting grant (111000C131) from IPCAS, a projects for Young Scientist from IPCAS (08CX043004), and a NNSF grant (30800301) to GJY; a projects for Young Scientist from IPCAS (07CX051005) and a NNSF grant (30700223) to WJY. |
| 语种 | 英语 |
| WOS记录号 | WOS:000282822500017 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20721]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Luo F |
| 作者单位 | Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
| 推荐引用方式 GB/T 7714 | Guo, JY,Wang, JY,Luo, F,et al. Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems[J]. Journal of Psychopharmacology,2010,24(10):1561-1567. |
| APA | Guo, JY,Wang, JY,Luo, F,&Luo F.(2010).Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems.Journal of Psychopharmacology,24(10),1561-1567. |
| MLA | Guo, JY,et al."Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems".Journal of Psychopharmacology 24.10(2010):1561-1567. |
入库方式： OAI收割
来源：心理研究所
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