Based on the main treatment functions such as organic micro-pollutants removal, mutagenicity reduce, coagulation aid, filtration aid, algae removal, odor removal and iron and manganese removal, the research, development and new achievements on the pre-oxidation technology of potassium permanganate composite chemicals in water supply treatment are presented in this thesis. Solutions presented in this thesis can be summarized as follows: -Potassium permanganate composite chemicals can remove organic micropollutants from source water effectively. -Treat with potassium permanganate composite chemicals can lower the mutagenicity of the water. -Pre-oxidation with potassium permanganate composite chemicals can disrupt the organic coatings, lead to particle destabilization, and save coagulant. -Pre-oxidation with potassium permanganate composite chemicals can distinctly improve algae removal in sedimentation and filtration. -Potassium permanganate composite chemicals can efficiently remove the odor causing by microorganisms as well as by chemical pollutants. -Potassium permanganate composite chemicals can efficiently remove not only the simple ion form iron and manganese in groundwater, but also the high stabilized iron and manganese complexed by the organic pollutants in surface water.