Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues
文献类型：期刊论文
| 作者 | Yu MR; Wang JL ; Yang YW; Zhu CL; Su Q; Guo SY; Sun JS; Gan Y; Shi XH(施兴华); Gao HJ
|
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2016 |
| 卷号 | 16期号:11页码:7176-7182 |
| 通讯作者邮箱 | ygan@simm.ac.cn ; shixh@nanoctr.cn ; huajian_Gao@brown.edu |
| 关键词 | Mucus penetration nanoparticle diffusion shape dependent molecular simulations transmucosal delivery |
| ISSN号 | 1530-6984 |
| 产权排序 | [Yu, Miaorong; Yang, Yiwei; Zhu, Chunliu; Guo, Shiyan; Gan, Yong] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; [Wang, Jiuling; Su, Qian; Sun, Jiashu; Shi, Xinghua] Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Nanosyst & Hierarchy Fabricat, Ctr Excellence Nanosci, Beijing 100190, Peoples R China; [Wang, Jiuling; Su, Qian; Shi, Xinghua] Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China; [Yu, Miaorong; Wang, Jiuling; Yang, Yiwei; Su, Qian; Sun, Jiashu; Gan, Yong; Shi, Xinghua] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; [Gao, Huajian] Brown Univ, Sch Engn, Providence, RI 02912 USA |
| 通讯作者 | Gan, Y (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China. ; Shi, XH (reprint author), Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Nanosyst & Hierarchy Fabricat, Ctr Excellence Nanosci, Beijing 100190, Peoples R China. ; Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China. ; Gan, Y ; Shi, XH (reprint author), Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China. ; Gao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA. |
| 中文摘要 | Mucus is a viscoelastic gel layer that typically protects exposed surfaces of the gastrointestinal (GI) tract, lung airways, and other mucosal tissues. Particles targeted to these tissues can be efficiently trapped and removed by mucus, thereby limiting the effectiveness of such drug delivery systems. In this study, we experimentally and theoretically demonstrated that cylindrical nanoparticles. (NPs), such as mesoporous silica nanorods and calcium phosphate nanorods, have superior transport and trafficking capability in mucus compared with spheres of the same chemistry. The higher diffusivity of nanorods leads to deeper mucus penetration and a longer retention time in the GI tract than that of their spherical counterparts. Molecular simulations and stimulated emission of depletion (STED) microscopy revealed that this anomalous phenomenon can be attributed to the rotational dynamics of the NPs facilitated by the mucin fibers and the shear flow. These findings shed new light on the shape design of NP-based drug delivery systems targeted to mucosal and tumor sites that possess a fibrous structure/porous medium. |
| 分类号 | 一类 |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | Mucus penetration ; nanoparticle diffusion ; shape dependent ; molecular simulations ; transmucosal delivery |
| 收录类别 | SCI ; EI |
| 原文出处 | http://dx.doi.org/10.1021/acs.nanolett.6b03515 |
| 语种 | 英语 |
| WOS记录号 | WOS:000387625000067 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/59956]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yu MR,Wang JL,Yang YW,et al. Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues[J]. NANO LETTERS,2016,16(11):7176-7182. |
| APA | Yu MR.,Wang JL.,Yang YW.,Zhu CL.,Su Q.,...&Gao HJ.(2016).Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues.NANO LETTERS,16(11),7176-7182. |
| MLA | Yu MR,et al."Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues".NANO LETTERS 16.11(2016):7176-7182. |
入库方式： OAI收割
来源：力学研究所
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