Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions
文献类型：期刊论文
| 作者 | Li L(李龙) ; Xu GK; Song F(宋凡)
|
| 刊名 | PHYSICAL REVIEW E
 |
| 出版日期 | 2017 |
| 卷号 | 95期号:1页码:12403 |
| 通讯作者邮箱 | songf@lnm.imech.ac.cn |
| ISSN号 | 2470-0045 |
| 产权排序 | [Li, Long; Song, Fan] Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China; [Li, Long; Song, Fan] Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing 100190, Peoples R China; [Xu, Guang-Kui] Xi An Jiao Tong Univ, Sch Aerosp, State Key Lab Strength & Vibrat Mech Struct, Int Ctr Appl Mech, Xian 710049, Peoples R China; [Song, Fan] Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Song, F (reprint author), Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China. ; Song, F (reprint author), Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing 100190, Peoples R China. ; Song, F (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China. |
| 中文摘要 | The interactions between T-cell receptor (TCR) and peptide-major-histocompatibility complex (pMHC), which enable T-cell development and initiate adaptive immune responses, have been intensively studied. However, a central issue of how lipid rafts affect the TCR-pMHC interactions remains unclear. Here, by using a statistical-mechanical membrane model, we show that the binding affinity of TCR and pMHC anchored on two apposing cell membranes is significantly enhanced because of the lipid raft-induced signaling protein aggregation. This finding may provide an alternative insight into the mechanism of T-cell activation triggered by very low densities of pMHC. In the case of cell-substrate adhesion, our results indicate that the loss of lateral mobility of the proteins on the solid substrate leads to the inhibitory effect of lipid rafts on TCR-pMHC interactions. Our findings help to understand why different experimental methods for measuring the impact of lipid rafts on the receptor-ligand interactions have led to contradictory conclusions. |
| 分类号 | 一类 |
| 类目[WOS] | Physics, Fluids & Plasmas ; Physics, Mathematical |
| 研究领域[WOS] | Physics |
| 收录类别 | SCI ; EI |
| 原文出处 | http://dx.doi.org/10.1103/PhysRevE.95.012403 |
| 语种 | 英语 |
| WOS记录号 | WOS:000391864200007 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/59959]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li L,Xu GK,Song F. Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions[J]. PHYSICAL REVIEW E,2017,95(1):12403. |
| APA | 李龙,Xu GK,&宋凡.(2017).Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions.PHYSICAL REVIEW E,95(1),12403. |
| MLA | 李龙,et al."Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions".PHYSICAL REVIEW E 95.1(2017):12403. |
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来源：力学研究所
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