Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog
文献类型：期刊论文
| 作者 | Feng, Yun1; Yang, Dazhang1; Chen, Hongbo2; Cheng, Wenli3; Wang, Lixia2; Sun, Hongxia2; Tang, Yalin2 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 26期号:7页码:1660-1663 |
| 关键词 | Bcl-2 gene P1 promoter G-quadruplex Pyridostatin analog Transcription |
| 英文摘要 | The G-quadruplexes located in the P1 promoter of B-cell lymphoma-2 (Bcl-2) gene are implicated to regulate Bcl-2 expression. Here, we designed a new pyridostatin analog named PDF, which exhibited high specificity and stabilizing effect toward G-quadruplexes. The luciferase assay demonstrated that PDF could significantly suppress Bcl-2 transcriptional activation in human laryngeal squamous carcinoma cells (Hep-2) cells. Besides, PDF also induced cell apoptosis in vitro assays. These results provide an excellent G-quadruplex specific ligand as an efficient Bcl-2 inhibitor. These results also implicate that PDF may be a potential anticancer drug to head neck cancer. (C) 2016 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35882]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.China Japan Friendship Hosp, Dept Otolaryngol, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Inst Chem, Beijing 100190, Peoples R China 3.China Japan Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Yun,Yang, Dazhang,Chen, Hongbo,et al. Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(7):1660-1663. |
| APA | Feng, Yun.,Yang, Dazhang.,Chen, Hongbo.,Cheng, Wenli.,Wang, Lixia.,...&Tang, Yalin.(2016).Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(7),1660-1663. |
| MLA | Feng, Yun,et al."Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.7(2016):1660-1663. |
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来源：化学研究所
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