Thrombin Ultrasensitive Detection Based on Chiral Supramolecular Assembly Signal-Amplified Strategy Induced by Thrombin-Binding Aptamer
文献类型：期刊论文
| 作者 | Shen, Gang1; Zhang, Hong1; Yang, Chunrong2; Yang, Qianfan2; Tang, Yalin1 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2017-01-03 |
| 卷号 | 89期号:1页码:548-551 |
| 英文摘要 | Thrombin plays a critical role in hemostasis and hemolysis. It is of high importance to develop a system toward thrombin detection with high sensitivity and high selectivity for both research and clinical diagnosis applications. In this paper, we developed a thrombin detection assay by taking advantage of the novel signal amplified strategy based on the chiral supramolecular assembly in physiological K background. This assay could detect thrombin as low concentration as about 2 pM and provided a highly specific selectivity among several common interferences. Furthermore, the assay can discriminate thrombin from other nonspecific analogous proteins with high selectivity and can be used to detect thrombin in diluted real human serum samples, which suggested its great potential for rapid detection of thrombin in the clinic. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/36323]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Chinese Acad Sci, Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Sichuan Univ, Coll Chem, Chengdu 610065, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Gang,Zhang, Hong,Yang, Chunrong,et al. Thrombin Ultrasensitive Detection Based on Chiral Supramolecular Assembly Signal-Amplified Strategy Induced by Thrombin-Binding Aptamer[J]. ANALYTICAL CHEMISTRY,2017,89(1):548-551. |
| APA | Shen, Gang,Zhang, Hong,Yang, Chunrong,Yang, Qianfan,&Tang, Yalin.(2017).Thrombin Ultrasensitive Detection Based on Chiral Supramolecular Assembly Signal-Amplified Strategy Induced by Thrombin-Binding Aptamer.ANALYTICAL CHEMISTRY,89(1),548-551. |
| MLA | Shen, Gang,et al."Thrombin Ultrasensitive Detection Based on Chiral Supramolecular Assembly Signal-Amplified Strategy Induced by Thrombin-Binding Aptamer".ANALYTICAL CHEMISTRY 89.1(2017):548-551. |
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来源：化学研究所
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