Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger
文献类型：期刊论文
| 作者 | Li, Jie1,2; Guan, Mirong1,2; Wang, Taishan1; Zhen, Mingming1,2; Zhao, Fuwen1,2; Shu, Chunying1; Wang, Chunru1,2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2016-10-05 |
| 卷号 | 8期号:39页码:25770-25776 |
| 关键词 | ROS scavenger Gd@C-82-(EDA)(8) nanoparticles conjugation cytoprotective effect cellular uptake |
| 英文摘要 | It is important to maintain a reactive oxygen species (ROS) balance in organisms; thus, a valid ROS scavenger with good biocompatibility is urgently required. To prepare a high-efficiency ROS scavenger, multiple ethylenediamine (EDA) groups are bonded for the first time to a metallofullerene Gd@C-82 to obtain water-soluble Gd@C-82-(EDA)(8) nanoparticles (NPs) through a facile solid liquid reaction. Gd@C-82-(EDA)(8) NPs with a relatively better conjugation possess an excellent capability to scavenge hydroxyl radicals. Moreover, Gd@C-82-(EDA)(8) NPs exhibited a remarkable cytoprotective effect against H2O2-induced injuries to human epidermal keratinocytes-adult (HEK-a) cells at a low concentration of 2.5 mu M. In contrast, Gd@C-82-(OH)(26) NPs that modified with hydroxyls show an apparent protective effect at a much higher concentration of 40 mu M. This outstanding cytoprotective performance of Gd@C-82-(EDA)(8) NPs is mainly attributed to their extremely high cellular uptake and comparably strong conjugation. Gd@C-82-(EDA)(8) NPs with good biocompatibility exhibit excellent ROS scavenging capability even at a significantly low concentration, which promotes its versatile applications in cosmetics and biomedicine. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35666]  |
| 专题 | 化学研究所_分子纳米结构与纳米技术实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jie,Guan, Mirong,Wang, Taishan,et al. Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(39):25770-25776. |
| APA | Li, Jie.,Guan, Mirong.,Wang, Taishan.,Zhen, Mingming.,Zhao, Fuwen.,...&Wang, Chunru.(2016).Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger.ACS APPLIED MATERIALS & INTERFACES,8(39),25770-25776. |
| MLA | Li, Jie,et al."Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger".ACS APPLIED MATERIALS & INTERFACES 8.39(2016):25770-25776. |
入库方式： OAI收割
来源：化学研究所
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