Synthesis and characterization of PLGA nanoparticle/4-arm-PEG hybrid hydrogels with controlled porous structures
文献类型：期刊论文
| 作者 | Zhuang, Yaping; Shen, Hong; Yang, Fei; Wang, Xing; Wu, Decheng |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:59页码:53804-53812 |
| 英文摘要 | Controlled porous structures, adjustable surface properties and good mechanical properties are essential for hydrogels in promoting cell adhesion and growth. In this work, we developed four armed poly(ethylene glycol) (4-arm-PEG) hydrogels crosslinked by poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs). Branched polyethyleneimine (b-PEI) was employed for aminolysis of PLGA to engineer 300, 530 and 1000 nm NPs with a nitrogen contents of 11.7%, 9.4% and 9.7%. Hybrid hydrogels were formed by crosslinking amino-packed NPs with polymeric chains of 4-arm-PEG-NHS. By manipulating the NP and PEG contents as well as the NP sizes, the pore sizes could be tailored from 10-20 mu m to 20-40 mu m and 100-200 mu m, and the maximal compressive strength could be optimized to 0.37 MPa. Cytotoxicity trials indicated the hydrogels were almost non-toxic and biocompatible. Cell adhesion evaluation testified higher amino contents and a smaller proportion of PEG led to more cell attachment. These results demonstrated that this kind of hybrid hydrogel may be a suitable candidate for further biomedical applications in tissue engineering. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35540]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhuang, Yaping,Shen, Hong,Yang, Fei,et al. Synthesis and characterization of PLGA nanoparticle/4-arm-PEG hybrid hydrogels with controlled porous structures[J]. RSC ADVANCES,2016,6(59):53804-53812. |
| APA | Zhuang, Yaping,Shen, Hong,Yang, Fei,Wang, Xing,&Wu, Decheng.(2016).Synthesis and characterization of PLGA nanoparticle/4-arm-PEG hybrid hydrogels with controlled porous structures.RSC ADVANCES,6(59),53804-53812. |
| MLA | Zhuang, Yaping,et al."Synthesis and characterization of PLGA nanoparticle/4-arm-PEG hybrid hydrogels with controlled porous structures".RSC ADVANCES 6.59(2016):53804-53812. |
入库方式： OAI收割
来源：化学研究所
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