Nano-rods of doxorubicin with poly(L-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment
文献类型：期刊论文
| 作者 | Yang, Saina1; Zhu, Feiyan2; Wang, Qian1; Liang, Fuxin1; Qu, Xiaozhong1,2; Gan, Zhihua3; Yang, Zhenzhong1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2016-12-07 |
| 卷号 | 4期号:45页码:7283-7292 |
| 英文摘要 | In addition to intravenous injections (i.v.), topical dosing of doxorubicin hydrochloride (DOX) has also been the focus of cancer treatment recently, although it normally requires well-designed drug carriers. In this work, we found that DOX could form fibril-shaped DOX aggregates via self-assembly in phosphate buffer (PB) and then co-assemble with poly(L-glutamic acid) (PGA) at a proper polymer-drug ratio, giving a unique nano-rod-shaped microstructure. The release rate of DOX from the PGA/DOX nano-rods was thus easily controlled at a slower release rate without being encapsulated by any classic carrier. In vitro cell culture demonstrated that the PGA/DOX nano-rods were not favorably taken up by cancer cells, which can be attributed to the negatively charged nature and the non-spherical shape of the aggregates. These features suggest great potential for the PGA/DOX assemblies for a sustained delivery through the intratumoral pathway (i.t.) as a carrier-free formulation. In the mouse model it diminished organ damage at a dose level of 30 mg kg(-1) via i.t. injections compared to the serious cardiotoxicity and renal toxicity via typical multiple i.v. dosage of free drug solution at 5 mg kg(-1). As a result, the PGA/DOX formulation showed efficient anti-tumor activity. The survival rate of tumor bearing mice was significantly increased by over 35% compared to the i.v. injections of DOX solutions. Therefore, PGA/DOX nano-rods may provide a new and safe delivery route of the common anti-tumor drug. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35678]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 3.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Saina,Zhu, Feiyan,Wang, Qian,et al. Nano-rods of doxorubicin with poly(L-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(45):7283-7292. |
| APA | Yang, Saina.,Zhu, Feiyan.,Wang, Qian.,Liang, Fuxin.,Qu, Xiaozhong.,...&Yang, Zhenzhong.(2016).Nano-rods of doxorubicin with poly(L-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment.JOURNAL OF MATERIALS CHEMISTRY B,4(45),7283-7292. |
| MLA | Yang, Saina,et al."Nano-rods of doxorubicin with poly(L-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment".JOURNAL OF MATERIALS CHEMISTRY B 4.45(2016):7283-7292. |
入库方式： OAI收割
来源：化学研究所
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