pH gradient difference around ischemic brain tissue can serve as a trigger for delivering polyethylene glycol-conjugated urokinase nanogels
文献类型：期刊论文
| 作者 | Cui, Wei1; Liu, Ran1; Jin, Haiqiang1; Lv, Pu1; Sun, Yuyao1; Men, Xi1; Yang, Saina2; Qu, Xiaozhong3; Yang, Zhenzhong2; Huang, Yining1 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2016-03-10 |
| 卷号 | 225页码:53-63 |
| 关键词 | Nanodrug Activity manipulation Targeted release Thrombolysis Blood-brain barrier |
| 英文摘要 | Background and Purpose: pH-sensitive polyethylene glycol-conjugated urokinase nanogels (PEG-UKs) were previously reported to be a new form of UK nanogels that could release UK at certain pH values. In this study, we evaluated the effect of PEG-UK targeted to ischemic tissue with microcirculation failure in rat model of ischemic stroke and investigated the possible mechanisms of action. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35863]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Peking Univ, Dept Neurol, Hosp 1, Beijing 100034, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Coll Mat & Optoelect Technol, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Wei,Liu, Ran,Jin, Haiqiang,et al. pH gradient difference around ischemic brain tissue can serve as a trigger for delivering polyethylene glycol-conjugated urokinase nanogels[J]. JOURNAL OF CONTROLLED RELEASE,2016,225:53-63. |
| APA | Cui, Wei.,Liu, Ran.,Jin, Haiqiang.,Lv, Pu.,Sun, Yuyao.,...&Huang, Yining.(2016).pH gradient difference around ischemic brain tissue can serve as a trigger for delivering polyethylene glycol-conjugated urokinase nanogels.JOURNAL OF CONTROLLED RELEASE,225,53-63. |
| MLA | Cui, Wei,et al."pH gradient difference around ischemic brain tissue can serve as a trigger for delivering polyethylene glycol-conjugated urokinase nanogels".JOURNAL OF CONTROLLED RELEASE 225(2016):53-63. |
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来源：化学研究所
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