Fabrication, hydrolysis and cell cultivation of microspheres from cellulose-graft-poly( L-lactide) copolymers
文献类型：期刊论文
| 作者 | Yang, Lili1,2; Zhang, Jinming1; He, Jiasong1; Zhang, Jun1; Gan, Zhihua3 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:21页码:17617-17623 |
| 英文摘要 | Porous microspheres of cellulose-graft-poly(L-lactide) (cellulose-g-PLLA) copolymers were fabricated by a water/oil/water (W/O/W) emulsion evaporation method. Their morphology, hydrophilicity and amount of hydroxyl group content (-OH content) on the surface were adjustable with the change of molar substitution of PLLA (MSPLLA). After a hydrolysis post-processing, surface physical properties of microspheres were regulated further. The influence of physical properties of microspheres on cell cultivation was investigated by setting hepatocellular liver carcinoma cell line (HepG-2) as the example. Compared with the cells on PLLA microspheres, HepG-2 cells with more pseudopods spread well on the surface of cellulose-g-PLLA microspheres. Particularly, the cellulose-g-PLLA microspheres with MSPLLA of 11.5 were the most appropriate candidate for cell adhesion and proliferation. Therefore, a moderate PLLA content of cellulose-g-PLLA copolymers was beneficial to the cell cultivation. This work indicated that combining cellulose with PLLA was an available route to developing cellulose-based materials for cell cultivation. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35876]  |
| 专题 | 化学研究所_工程塑料实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 2.China Univ Petr, State Key Lab Petr Resources & Prospecting, Beijing 102249, Peoples R China 3.Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomat, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Lili,Zhang, Jinming,He, Jiasong,et al. Fabrication, hydrolysis and cell cultivation of microspheres from cellulose-graft-poly( L-lactide) copolymers[J]. RSC ADVANCES,2016,6(21):17617-17623. |
| APA | Yang, Lili,Zhang, Jinming,He, Jiasong,Zhang, Jun,&Gan, Zhihua.(2016).Fabrication, hydrolysis and cell cultivation of microspheres from cellulose-graft-poly( L-lactide) copolymers.RSC ADVANCES,6(21),17617-17623. |
| MLA | Yang, Lili,et al."Fabrication, hydrolysis and cell cultivation of microspheres from cellulose-graft-poly( L-lactide) copolymers".RSC ADVANCES 6.21(2016):17617-17623. |
入库方式： OAI收割
来源：化学研究所
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