Nd3+ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application
文献类型：期刊论文
| 作者 | Xu, Bing1; Zhang, Xiao2,3; Huang, Wenjuan1; Yang, Yijun4; Ma, Ying1; Gu, Zhanjun2,3; Zhai, Tianyou1; Zhao, Yuliang2,3 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2016 |
| 卷号 | 4期号:16页码:2776-2784 |
| 英文摘要 | Better tissue penetration and lower overheating problems mean 808 nm near-infrared laser excited upconversion nanoparticles (UCNPs) have potential in bioapplications. Dumbbell-like structured NaYF4:Yb/Er@NaNdF4:Yb nanoparticles are fabricated in this work and applied in photodynamic therapy (PDT). The epitaxial growth along the c axis attributed to the large structure mismatch of NaNdF4 versus NaYF4 has been demonstrated to play a key role in the growth of the dumbbell structure. Due to better space separation in this structure, energy back-transfer from Er3+ to Nd3+ is prohibited partially, and the optimized Nd3+ doping concentration is up to 90% for a high UC emission intensity. PDT effects of these dumbbell-like structured UCNPs upon 808 nm laser irradiation were examined and compared with isotropic NaYF4:Yb/Er@NaYF4:Nd-0.2 core-shell and NaYF4:Yb/Er@NaYF4:Nd-0.2@NaYF4 core-shell-shell UCNPs. The results show that the dumbbell-like UCNPs are most effective in generating singlet oxygen (O-1(2)) and killing cancer cells in PDT though their UC emission intensity is lower than that of the core-shell-shell UCNPs. This research presents a simple yet valid strategy to balance the UCL efficiency and FRET efficiency, which may lead to better PDT therapeutic effect for cancer therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/36069]  |
| 专题 | 化学研究所_光化学实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Mat Sci & Engn, State Key Lab Mat Proc & Die & Mould Technol, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Chem, CAS Key Lab Photochem, BNLMS, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Bing,Zhang, Xiao,Huang, Wenjuan,et al. Nd3+ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(16):2776-2784. |
| APA | Xu, Bing.,Zhang, Xiao.,Huang, Wenjuan.,Yang, Yijun.,Ma, Ying.,...&Zhao, Yuliang.(2016).Nd3+ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application.JOURNAL OF MATERIALS CHEMISTRY B,4(16),2776-2784. |
| MLA | Xu, Bing,et al."Nd3+ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application".JOURNAL OF MATERIALS CHEMISTRY B 4.16(2016):2776-2784. |
入库方式： OAI收割
来源：化学研究所
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