Synchronous Detection of Rat Neural Spike Firing and Neurochemical Signals Based on Dual-mode Recording Instrument
文献类型：期刊论文
| 作者 | Xu Sheng-Wei1,2; Wang Li1,2; Song Xian-Teng1,2; Zhang Song1,2; Wang Mi-Xia1; Yu Ping2,3; Mao Lan-Qun2,3; Cai Xin-Xia1,2 |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 44期号:9页码:1457-1463 |
| 关键词 | Dual-mode Neurochemistry Spike Ascorbic acid Microelectrode |
| 英文摘要 | A dual-mode recording system used for synchronous detection of neuroeletrical and neurochemical signals was developed, and a dual-mode synchronous detection experiment was carried out using this instrument. The device comprised a 64-channel neuroelectricity recording module with voltage resolution of 0.3 mu V and a 4-channel neurochemistry recording module with current resolution of 1 pA. The software had many basic detection features as spike separation and sort, chronoamperometry, cyclic voltammetry, etc. In particular, the software could observe and analyze the dual-mode neural signals synchronously. The performance of the system was demonstrated in the single mode detection experiments. In neuroeletrical experiments, 64-channel simulate neural signals were detected and the signal-to-noise ratio (S/N) of spike recorded from cortex of Sprague-Dawley (SD) rat was 6. In the K-3[Fe(CN)(6)] and ascorbic acid measurement experiments, the current response of K-3[Fe(CN)(6)] in the range of 0.1-10 mM was obtained by cyclic voltammetry, with a correlation coefficient of 0.9889, and the current response of ascorbic acid (10-800 mu M) by chronoamperometry increased linearly with a correlation coefficient of 0.9841. Based on the rat model of global cerebral ischemia, a dual-mode detection experiment was carried out. In the experiment, the neuroelectrical and neurochemical signals were synchronously recorded in the SD rat primary visual cortex. According to the experimental results, we got the conclusion that the concentration of ascorbic acid negatively related to the spike firing in the SD rat primary visual cortex. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35479]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Elect, State Key Lab Transducer Technol, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 10090, Peoples R China 3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu Sheng-Wei,Wang Li,Song Xian-Teng,et al. Synchronous Detection of Rat Neural Spike Firing and Neurochemical Signals Based on Dual-mode Recording Instrument[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2016,44(9):1457-1463. |
| APA | Xu Sheng-Wei.,Wang Li.,Song Xian-Teng.,Zhang Song.,Wang Mi-Xia.,...&Cai Xin-Xia.(2016).Synchronous Detection of Rat Neural Spike Firing and Neurochemical Signals Based on Dual-mode Recording Instrument.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,44(9),1457-1463. |
| MLA | Xu Sheng-Wei,et al."Synchronous Detection of Rat Neural Spike Firing and Neurochemical Signals Based on Dual-mode Recording Instrument".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 44.9(2016):1457-1463. |
入库方式： OAI收割
来源：化学研究所
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