Generating Cell Targeting Aptamers for Nanotheranostics Using Cell-SELEX
文献类型：期刊论文
| 作者 | Lyu, Yifan; Chen, Guang; Shangguan, Dihua; Zhang, Liqin; Wan, Shuo; Wu, Yuan; Zhang, Hui; Duan, Lian; Liu, Chao; You, Mingxu |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:9页码:1440-1452 |
| 关键词 | Aptamers Cell-SELEX nanotheranostic aptamer drug conjugates DNA network |
| 英文摘要 | Detecting and understanding changes in cell conditions on the molecular level is of great importance for the accurate diagnosis and timely therapy of diseases. Cell-based SELEX (Systematic Evolution of Ligands by EXponential enrichment), a foundational technology used to generate highly-specific, cell-targeting aptamers, has been increasingly employed in studies of molecular medicine, including biomarker discovery and early diagnosis/targeting therapy of cancer. In this review, we begin with a mechanical description of the cell-SELEX process, covering aptamer selection, identification and identification, and aptamer characterization; following this introduction is a comprehensive discussion of the potential for aptamers as targeting moieties in the construction of various nanotheranostics. Challenges and prospects for cell-SELEX and aptamer-based nanotheranostic are also discussed. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35546]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiol, Beijing 100053, Peoples R China 2.Hunan Univ, Collaborat Innovat Ctr Chem & Mol Med, Mol Sci & Biomed Lab,Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr,Coll B, Changsha 410082, Hunan, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Univ Florida, McKnight Brain Inst, Dept Chem & Physiol & Funct Genom, Ctr Res Bio Nano Interface,Hlth Canc Ctr,UF Genet, Gainesville, FL 32611 USA |
| 推荐引用方式 GB/T 7714 | Lyu, Yifan,Chen, Guang,Shangguan, Dihua,et al. Generating Cell Targeting Aptamers for Nanotheranostics Using Cell-SELEX[J]. THERANOSTICS,2016,6(9):1440-1452. |
| APA | Lyu, Yifan.,Chen, Guang.,Shangguan, Dihua.,Zhang, Liqin.,Wan, Shuo.,...&Tan, Weihong.(2016).Generating Cell Targeting Aptamers for Nanotheranostics Using Cell-SELEX.THERANOSTICS,6(9),1440-1452. |
| MLA | Lyu, Yifan,et al."Generating Cell Targeting Aptamers for Nanotheranostics Using Cell-SELEX".THERANOSTICS 6.9(2016):1440-1452. |
入库方式： OAI收割
来源：化学研究所
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