A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots
文献类型：期刊论文
| 作者 | Huang, Yuanyuan1; Zhou, Jin2; Feng, Hui1; Zheng, Jieyu1; Ma, Hui-Min2; Liu, Weidong1; Tang, Cong1; Ao, Hang1; Zhao, Meizhi1; Qian, Zhaosheng1 |
| 刊名 | BIOSENSORS & BIOELECTRONICS
 |
| 出版日期 | 2016-12-15 |
| 卷号 | 86页码:748-755 |
| 关键词 | Carbon quantum dots Chemosensor Fluorometric assay Glutathione detection |
| 英文摘要 | A convenient, fluorescent dual-channel chemosensor on the basis of bis(3-pyridylmethyl)amine-functionalized carbon quantum dots (BPMA-CQDs) nanoprobe was constructed, and it can discriminatively detect glutathione from its analogues cysteine and homocysteine based on two distinctive strategies. Two distinct fluorescence responses of BPMA-CQDs probe to Cu(II) and Ag(I) were identified and further employed to achieve selective detection of Cu(II) and Ag(I) respectively. Based on the BPMA-CQDs/Cu(II) conjugate, discriminative detection of GSH was achieved in terms of correlation between the amounts of GSH and fluorescence recovery. The addition of GSH into BPMA-CQDs/Cu(II) system induces the reduction of Cu(II) to Cu(l), which could efficiently block PET process resulting in the following fluorescence recovery. Based on the BPMA-CQDs/Ag(I) conjugate, GSH assay could also be established on the basis of fluorescence response to GSH. The introduction of GSH into the preceding system triggers the competitive coordination to Ag(l) between BPMA and GSH, and silver ions are finally taken away by GSH from the probe, where the fluorescence is restored to its original weak state. Both of the detection strategies can achieve discriminative detection of GSH from Cys and Hcy. The assays showed good stability and repeatability, and covered a broad linear range of up to 13.3 mu M with a lowest detection limit of 42.0 nM. Moreover, both of them were utilized to monitor GSH level in live cells. (C) 2016 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35638]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Zhejiang Normal Univ, Coll Chem & Life Sci, Jinhua 321004, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yuanyuan,Zhou, Jin,Feng, Hui,et al. A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots[J]. BIOSENSORS & BIOELECTRONICS,2016,86:748-755. |
| APA | Huang, Yuanyuan.,Zhou, Jin.,Feng, Hui.,Zheng, Jieyu.,Ma, Hui-Min.,...&Qian, Zhaosheng.(2016).A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots.BIOSENSORS & BIOELECTRONICS,86,748-755. |
| MLA | Huang, Yuanyuan,et al."A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots".BIOSENSORS & BIOELECTRONICS 86(2016):748-755. |
入库方式： OAI收割
来源：化学研究所
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