Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes
文献类型：期刊论文
| 作者 | Zheng, Wei1,2,3,4,5; Zhao, Yao1,2,3,4,5; Luo, Qun1,2,3,4,5; Zhang, Yang1,2,3,4,5; Wu, Kui1,2,3,4,5; Wang, Fuyi1,2,3,4,5 |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 59期号:10页码:1240-1249 |
| 关键词 | anticancer agents metal complexes multi-targeting EGFR-inhibition DNA binding |
| 英文摘要 | Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrinsic or acquired drug resistance profoundly limit their application, which encourages the development of novel transition metal-based anticancer agents with different mechanisms of action. To this end, transition metal complexes that can simultaneously act on more than one target, termed as single-molecule multi-targeting complexes, have attracted increasing attention because of their enhanced efficacy and diminished chance of drug resistance. In this review, we systematically discuss the recent progress in the development of platinum- and ruthenium-based anticancer agents, in particular the rational design of platinum and ruthenium complexes with multi-targeting features. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35644]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Natl Ctr Mass Spectrometry Beijing, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Wei,Zhao, Yao,Luo, Qun,et al. Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes[J]. SCIENCE CHINA-CHEMISTRY,2016,59(10):1240-1249. |
| APA | Zheng, Wei,Zhao, Yao,Luo, Qun,Zhang, Yang,Wu, Kui,&Wang, Fuyi.(2016).Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes.SCIENCE CHINA-CHEMISTRY,59(10),1240-1249. |
| MLA | Zheng, Wei,et al."Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes".SCIENCE CHINA-CHEMISTRY 59.10(2016):1240-1249. |
入库方式： OAI收割
来源：化学研究所
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