A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer
文献类型：期刊论文
| 作者 | Boison, Daniel1,2,4; Lu, Wen-Long1; Xu, Qin-Mei3; Yang, Huang1; Huang, Tao2; Chen, Qiu-Yun1; Gao, Jing2; Zhao, Yao5 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2016-11-01 |
| 卷号 | 147页码:387-396 |
| 关键词 | Anticancer Manganese nanoparticle Mitochondria Apoptosis Imaging |
| 英文摘要 | HIF-1 alpha and LDH-A are important targets for hypoxia-driven drug resistance. Mitochondria targeted fluorescent manganese(II)-complexes can be used as potential fluorescence imaging agents, MRI contrast agents and HIF-1 alpha and LDH-A involved anticancer complexes. In this study, a fluorescent manganese(II) nanoparticle, labeled as (PEG-Mn-BDA), was synthesized and used as both fluorescent and MRI imaging agents in cancer cells. In vitro bioassay results indicate that PEG-Mn-BDA was able to inhibit LDH-A activity and depolarize mitochondrial membrane potential with the generation of intracellular ROS, which contributed to the induction of apoptosis. Moreover, the pro-apoptotic protein, caspase 3 was highly expressed. In vivo, PEG-Mn-BDA could also exert inhibition on a mouse hepatocellular carcinoma xenograft. These results suggest that mitochondria targeted PEG-Mn-BDA was able to simultaneously induce selective inhibition on cancer cells and a mouse carcinoma xenograft, label cancer cells with fluorescence and enhance MRI contrast. Therefore, PEG-Mn-BDA is a good candidate for cancer treatment and imaging. (C) 2016 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35667]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Peoples R China 2.Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Peoples R China 3.Southeast Univ, Zhongda Hosp, Sch Med, Jiangsu Key Lab Mol & Funct Imaging,Dept Radiol, Nanjing 210009, Peoples R China 4.Univ Cape Coast, Sch Biol Sci, Dept Biochem, Cape Coast, Ghana 5.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Boison, Daniel,Lu, Wen-Long,Xu, Qin-Mei,et al. A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2016,147:387-396. |
| APA | Boison, Daniel.,Lu, Wen-Long.,Xu, Qin-Mei.,Yang, Huang.,Huang, Tao.,...&Zhao, Yao.(2016).A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer.COLLOIDS AND SURFACES B-BIOINTERFACES,147,387-396. |
| MLA | Boison, Daniel,et al."A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer".COLLOIDS AND SURFACES B-BIOINTERFACES 147(2016):387-396. |
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来源：化学研究所
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