Gelatin-Assisted Synthesis of Vaterite Nanoparticles with Higher Surface Area and Porosity as Anticancer Drug Containers In Vitro
文献类型：期刊论文
| 作者 | Wang, Anhe1; Yang, Yang1; Zhang, Xiaoming1; Liu, Xingcen2; Cui, Wei2; Li, Junbai2 |
| 刊名 | CHEMPLUSCHEM
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 81期号:2页码:194-201 |
| 关键词 | doxorubicin drug delivery gelatin-assisted synthesis pH-responsive materials vaterite nanoparticles |
| 英文摘要 | The fabrication of porous vaterite nanoparticles with improved stability in aqueous solution and higher surface area is still a challenge. Here, inspired by the formation of mesoporous silica nanoparticles, we have taken gelatin as a surfactant to assist in the formation of vaterite nanoparticles and help create pores on their surface due to the distinct solubility and molecular morphology of gelatin in different solutions. The formation mechanism of vaterite nanoparticles and pores was investigated in detail, indicating that the existence of gelatin has a crucial effect on the formation of vaterite nanoparticles and their stability. Meanwhile, the elution of gelatin from vaterite nanoparticles via washing with hot water accounts for their higher surface area. Their application as an anticancer drug (doxorubicin) carrier after folic acid treatment was also investigated. These nanoparticles have advantages for drug release due to their pH-sensitive structure and also have enhanced cytotoxicity toward cancer cells due to the folic acid modification. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35819]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, Bei Yi Tiao 11, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Key Lab Colloid Interface & Chem Thermodynam, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Anhe,Yang, Yang,Zhang, Xiaoming,et al. Gelatin-Assisted Synthesis of Vaterite Nanoparticles with Higher Surface Area and Porosity as Anticancer Drug Containers In Vitro[J]. CHEMPLUSCHEM,2016,81(2):194-201. |
| APA | Wang, Anhe,Yang, Yang,Zhang, Xiaoming,Liu, Xingcen,Cui, Wei,&Li, Junbai.(2016).Gelatin-Assisted Synthesis of Vaterite Nanoparticles with Higher Surface Area and Porosity as Anticancer Drug Containers In Vitro.CHEMPLUSCHEM,81(2),194-201. |
| MLA | Wang, Anhe,et al."Gelatin-Assisted Synthesis of Vaterite Nanoparticles with Higher Surface Area and Porosity as Anticancer Drug Containers In Vitro".CHEMPLUSCHEM 81.2(2016):194-201. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。