Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells
文献类型：期刊论文
| 作者 | Zhang, Pengbo; Lu, Huan; Chen, Hui; Zhang, Jiangyan; Liu, Libing; Lv, Fengting; Wang, Shu |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2016-03-15 |
| 卷号 | 88期号:6页码:2985-2988 |
| 英文摘要 | Bacteria quorum sensing (QS) has attracted significant interest for understanding cell cell communication and regulating biological functions. In this work, we demonstrate that water-soluble cationic conjugated polymers (PFP-G2) can interact with bacteria to form aggregates through electrostatic interactions. With bacteria coated in the aggregate, PFP-G2 can induce the bacteria QS system and prolong the time duration of QS signal molecules (autoinducer-2 (AI-2)) production. The prolonged AI-2 can bind with specific protein and continuously regulate downstream gene expression. Consequently, the bacteria show a higher survival rate against antibiotics,: resulting in decreased antimicrobial susceptibility. Also, AI-2 induced by PFP-G2 can stimulate 55.54 +/- 12.03% more biofilm in E. coli. This method can be used to understand cell cell communication and regulate biological functions, such as the production of signaling molecules, antibiotics, other microbial metabolites, and even virulence. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35926]  |
| 专题 | 化学研究所_有机固体实验室 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Pengbo,Lu, Huan,Chen, Hui,et al. Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells[J]. ANALYTICAL CHEMISTRY,2016,88(6):2985-2988. |
| APA | Zhang, Pengbo.,Lu, Huan.,Chen, Hui.,Zhang, Jiangyan.,Liu, Libing.,...&Wang, Shu.(2016).Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells.ANALYTICAL CHEMISTRY,88(6),2985-2988. |
| MLA | Zhang, Pengbo,et al."Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells".ANALYTICAL CHEMISTRY 88.6(2016):2985-2988. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。