Regulation of oxidative stress inside living cells through polythiophene derivatives
文献类型：期刊论文
| 作者 | Hu, Rong; Li, Sheng-Liang; Bai, Hao-Tian; Wang, Yun-Xia; Liu, Li-Bing; Lv, Feng-Ting; Wang, Shu |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 27期号:4页码:545-549 |
| 关键词 | Angiotensin II Oxidative stress Conjugated polymer Dihydropiridine Regulation |
| 英文摘要 | Oxidative stress stimulated by angiotensin II (Ang II) plays an important role in the progression of inflammation and cardiovascular disease. In this work, polythiophene modified with dihydropyridine groups (PTDHP) realized the control of oxidative stress induced by Angiotensin II stimulation in living cells, by inhibiting the activity of NADPH oxidase via DHP groups. Upon light irradiation, the PcDHP could sensitize surrounding oxygen molecules to generate reactive oxygen species (ROS). The generated ROS oxidized the pendant DHP of polythiophene into pyridine group, which inactivated the control ability of DHP to oxidative stress in living cells. Thus, PTDHP can not only control the intracellular oxidative stress effectively and suppress ROS to some degree in dark, but also regulate its anti-oxidative effect under light irradiation. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/36057]  |
| 专题 | 化学研究所_有机固体实验室 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Rong,Li, Sheng-Liang,Bai, Hao-Tian,et al. Regulation of oxidative stress inside living cells through polythiophene derivatives[J]. CHINESE CHEMICAL LETTERS,2016,27(4):545-549. |
| APA | Hu, Rong.,Li, Sheng-Liang.,Bai, Hao-Tian.,Wang, Yun-Xia.,Liu, Li-Bing.,...&Wang, Shu.(2016).Regulation of oxidative stress inside living cells through polythiophene derivatives.CHINESE CHEMICAL LETTERS,27(4),545-549. |
| MLA | Hu, Rong,et al."Regulation of oxidative stress inside living cells through polythiophene derivatives".CHINESE CHEMICAL LETTERS 27.4(2016):545-549. |
入库方式： OAI收割
来源：化学研究所
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