Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma
文献类型：期刊论文
| 作者 | Hou XD(侯小东); Zhang T(张涛); Cao AM(曹阿民) |
| 刊名 | J. Biomed. Mater. Res. Part B
 |
| 出版日期 | 2015 |
| 卷号 | 103期号:1页码:52-61 |
| 其他题名 | Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma |
| 通讯作者 | 侯小东 ; 曹阿民 |
| 英文摘要 | In the present work, new amphiphilic macroporous polymeric adsorbent (AMPA) membranes for LDL-apheresis were prepared by Co-60 -ray irradiation-induced grafting copolymerization of polypropylene (PP) nonwoven fabric with acrylic acid, followed by bonding cholesterol through linkers of different length. The new AMPA membranes were characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscope (SEM), and contact angle microscopy. Static adsorption and hemo-perfusion tests show these new adsorbents could efficiently remove LDL from human plasma. Meanwhile, the AMPA displayed good adsorption capacity for triglyceride (TG) as well. The static adsorption performance of the AMPA membranes depends on the length of linker. In addition, a balance between the amount of bonded cholesterol and remaining carboxyl group was found necessary to reach the optimal adsorption performance. The best result was achieved by the AMPA membrane PA(15)C(6)-3, by which 62.8 +/- 3.8 g of LDL-C, 16.5 +/- 0.71 g of HDL-C, 132.4 +/- 3.0 g of TG are removed from human plasma per square centimeter. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 52-61, 2015. |
| 学科主题 | 高分子化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/jbm.b.33190 |
| 语种 | 英语 |
| WOS记录号 | WOS:000346191600007 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39831]  |
| 专题 | 上海有机化学研究所_高分子材料研究室 |
| 作者单位 | 中科院上海有机化学研究所, 高分子材料研究室 |
| 推荐引用方式 GB/T 7714 | Hou XD,Zhang T,Cao AM. Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma[J]. J. Biomed. Mater. Res. Part B,2015,103(1):52-61. |
| APA | 侯小东,张涛,&曹阿民.(2015).Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma.J. Biomed. Mater. Res. Part B,103(1),52-61. |
| MLA | 侯小东,et al."Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma".J. Biomed. Mater. Res. Part B 103.1(2015):52-61. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。