Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier
文献类型：期刊论文
| 作者 | Xu ZY(徐志远)1; Zhu SJ(朱绍佳)1; Wang MW(王明伟)1; Li YJ(李永军)1; Shi P(史萍)1; Huang XY(黄晓宇)1 |
| 刊名 | ACS Appl. Mater. Interfaces
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:2页码:1355-1363 |
| 其他题名 | Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier |
| 通讯作者 | 史萍 ; 黄晓宇 |
| 英文摘要 | Paclitaxel (PTX) is an extensively used potent chemotherapy drug; however, low water solubility, poor bioavailability, and emergence of drug resistance in patients limited its biological application. In this report, we proposed a new drug delivery system for cancer therapy based on graphene oxide (GO), a novel 2D nanomaterial obtained from the oxidation of natural graphite, to improve the utilization rate of PTX. PTX was first connected to biocompatible 6-armed poly(ethylene glycol), followed by covalent introduction into the surface of GO sheets via a facile amidation process under mild conditions, affording the drug delivery system, GO-PEG-PTX (size 50200 nm). GO-PEG nanosized carrier could quickly enter into human lung cancer A549 and human breast cancer MCF-7 cells verified by inverted fluorescence microscope using fluorescein isothiocyanate as probe. This nanocarrier was nontoxic to A549 and MCF-7 cells without linking with PTX. Nevertheless, GO-PEG-PTX showed remarkably high cytotoxicity to A549 and MCF-7 cells in a broad range of concentration of PTX and time compared to free PTX. This kind of nanoscale drug delivery system based on PEGylated GO may find widespread application in biomedicine. |
| 学科主题 | 高分子化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/am507798d |
| 语种 | 英语 |
| WOS记录号 | WOS:000348332700039 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39835]  |
| 专题 | 上海有机化学研究所_高分子材料研究室 |
| 作者单位 | 1.中科院上海有机化学研究所, 有机功能分子合成与组装化学重点实验室 2.华东理工大学 3.复旦大学肿瘤医院 |
| 推荐引用方式 GB/T 7714 | Xu ZY,Zhu SJ,Wang MW,et al. Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier[J]. ACS Appl. Mater. Interfaces,2015,7(2):1355-1363. |
| APA | 徐志远,朱绍佳,王明伟,李永军,史萍,&黄晓宇.(2015).Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier.ACS Appl. Mater. Interfaces,7(2),1355-1363. |
| MLA | 徐志远,et al."Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier".ACS Appl. Mater. Interfaces 7.2(2015):1355-1363. |
入库方式： OAI收割
来源：上海有机化学研究所
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