Efficient synthesis of baicalin and its analogs
文献类型：期刊论文
| 作者 | Li YF(李杨峰)1; Yu B(俞飚)1; Sun JS(孙建松)1; Wang RX(王任小)1 |
| 刊名 | Tetrahedron Lett.
 |
| 出版日期 | 2015 |
| 卷号 | 56期号:24页码:3816-3819 |
| 其他题名 | 黄芩苷和其类似物的高效合成法 |
| 通讯作者 | 孙建松 ; 王任小 |
| 英文摘要 | Baicalin is the most abundant ingredient of Scutellaria baicalensis, which has been shown to have a variety of biological activities. In this study, we have developed an efficient synthetic route for this compound based on Koenigs-Knorr glycosylation and mild-basic deprotection. Through this route, baicalin was obtained from cheap starting materials in a linear longest 10-step sequence with an overall yield of 27%. Four analogs of baicalin were also synthesized in high yields with the key protocols developed in the synthesis of baicalin, demonstrating the general applicability of our synthetic route. Efficient synthesis of baicalin and its analogs will hopefully facilitate further structure-activity relationship studies of this class of compounds. (C) 2015 Elsevier Ltd. All rights reserved. |
| 学科主题 | 计算机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tetlet.2015.04.083 |
| 语种 | 英语 |
| WOS记录号 | WOS:000356554900024 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39822]  |
| 专题 | 上海有机化学研究所_计算机化学与化学信息学研究室 |
| 作者单位 | 1.中科院上海有机化学研究所, 生命有机化学国家重点实验室 2.江西师范大学 3.澳门科技大学 |
| 推荐引用方式 GB/T 7714 | Li YF,Yu B,Sun JS,et al. Efficient synthesis of baicalin and its analogs[J]. Tetrahedron Lett.,2015,56(24):3816-3819. |
| APA | 李杨峰,俞飚,孙建松,&王任小.(2015).Efficient synthesis of baicalin and its analogs.Tetrahedron Lett.,56(24),3816-3819. |
| MLA | 李杨峰,et al."Efficient synthesis of baicalin and its analogs".Tetrahedron Lett. 56.24(2015):3816-3819. |
入库方式： OAI收割
来源：上海有机化学研究所
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