A General and Mild Catalytic alpha-Alkylation of Unactivated Esters Using Alcohols
文献类型：期刊论文
| 作者 | Guo L(郭乐); Ma XC(马笑晨); Fang HQ(方华权); Jia XQ(贾香清); Huang Z(黄正) |
| 刊名 | Angew. Chem.-Int. Edit.
 |
| 出版日期 | 2015 |
| 卷号 | 54期号:13页码:4023-4027 |
| 其他题名 | 一种普遍且温和的利用醇进行非活化酯的alfa烷基化方法 |
| 通讯作者 | 黄正 |
| 英文摘要 | Catalytic alpha-alkylation of esters with primary alcohols is a desirable process because it uses low-toxicity agents and generates water as the by-product. Reported herein is a NCP pincer/Ir catalyst which is highly efficient for alpha-alkylation of a broad scope of unactivated esters under mild reaction conditions. For the first time, alcohols alkylate unactivated a-substituted acyclic esters, lactones, and even methyl and ethyl acetates. This method can be applied to the synthesis of carboxylic acid derivatives with diverse structures and functional groups, some of which would be impossible to access by conventional enolate alkylations with alkyl halides. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/anie.201410293 |
| 语种 | 英语 |
| WOS记录号 | WOS:000351204600031 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39571]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 作者单位 | 中科院上海有机化学研究所, 金属有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Guo L,Ma XC,Fang HQ,et al. A General and Mild Catalytic alpha-Alkylation of Unactivated Esters Using Alcohols[J]. Angew. Chem.-Int. Edit.,2015,54(13):4023-4027. |
| APA | 郭乐,马笑晨,方华权,贾香清,&黄正.(2015).A General and Mild Catalytic alpha-Alkylation of Unactivated Esters Using Alcohols.Angew. Chem.-Int. Edit.,54(13),4023-4027. |
| MLA | 郭乐,et al."A General and Mild Catalytic alpha-Alkylation of Unactivated Esters Using Alcohols".Angew. Chem.-Int. Edit. 54.13(2015):4023-4027. |
入库方式： OAI收割
来源：上海有机化学研究所
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