FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation
文献类型：期刊论文
| 作者 | XIAO JUAN1; ZHANG TAO1; XU DAICHAO1; WANG HUIBING1; CAI YU1; JIN TAIJIE1; LIU MIN1; JIN MINGZHI1; WU KEJIA1; Yuan JY(袁钧瑛)1 |
| 刊名 | Genes Dev.
 |
| 出版日期 | 2015 |
| 卷号 | 29期号:2页码:184-196 |
| 其他题名 | FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation |
| 英文摘要 | Vacuolar protein-sorting 34 (Vps34), the catalytic subunit in the class III PtdIns3 (phosphatidylinositol 3) kinase complexes, mediates the production of PtdIns3P, a key intracellular lipid involved in regulating autophagy and receptor degradation. However, the signal transduction pathways by which extracellular signals regulate Vps34 complexes and the downstream cellular mechanisms are not well understood. Here we show that DNA damage-activated mitotic arrest and CDK activation lead to the phosphorylation of Vps34, which provides a signal to promote its ubiquitination and proteasomal degradation mediated by FBXL20 (an F-box protein) and the associated Skp1 (S-phase kinase-associated protein-1)-Cullin1 complex, leading to inhibition of autophagy and receptor endocytosis. Furthermore, we show that the expression of FBXL20 is regulated by p53-dependent transcription. Our study provides a molecular pathway by which DNA damage regulates Vps34 complexes and its downstream mechanisms, including autophagy and receptor endocytosis, through SCF (Skp1-Cul1-F-box)-mediated ubiquitination and degradation. Since the expression of FBXL20 is regulated by p53-dependent transcription, the control of Vps34 ubiquitination and proteasomal degradation by FBXL20 and the associated SCF complex expression provides a novel checkpoint for p53 to regulate autophagy and receptor degradation in DNA damage response. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1101/gad.252528.114 |
| 语种 | 英语 |
| WOS记录号 | WOS:000347969500007 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39478]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 作者单位 | 1.中科院上海有机化学研究所, 生物与化学交叉研究中心 2.美国哈佛大学 |
| 推荐引用方式 GB/T 7714 | XIAO JUAN,ZHANG TAO,XU DAICHAO,et al. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation[J]. Genes Dev.,2015,29(2):184-196. |
| APA | XIAO JUAN.,ZHANG TAO.,XU DAICHAO.,WANG HUIBING.,CAI YU.,...&袁钧瑛.(2015).FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation.Genes Dev.,29(2),184-196. |
| MLA | XIAO JUAN,et al."FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation".Genes Dev. 29.2(2015):184-196. |
入库方式： OAI收割
来源：上海有机化学研究所
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