Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers
文献类型：期刊论文
| 作者 | Qiu HB(邱海波); Qian WJ(钱文建); Yu SM(于顺明); Yao ZJ(姚祝军) |
| 刊名 | Tetrahedron
 |
| 出版日期 | 2015 |
| 卷号 | 71期号:2页码:370-380 |
| 其他题名 | Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers |
| 通讯作者 | 姚祝军 |
| 英文摘要 | Chlorofusin (1), one of few natural antagonists against p53-MDM2 interactions, is a naturally biogenetic hybrid composed of a 27-membered nonacyclopeptide and a unique chromophore through the hydrocarbon linkage with ornithine. In this article, we describe our recent achievement, in details, of developing a convenient stereodivergent route for parallel total synthesis of chlorofusin (1) and its all seven chromophore diastereomers (1a-1g) in enantiopure forms, starting from a common racemic azaphilone precursor 10. The newly developed total synthesis shows the great advantages of economy, scalability, stable intermediates, high yields, ease of HPLC-free operations and reduplication. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tet.2014.10.062 |
| 语种 | 英语 |
| WOS记录号 | WOS:000348083200019 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39479]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 作者单位 | 中科院上海有机化学研究所, 生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Qiu HB,Qian WJ,Yu SM,et al. Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers[J]. Tetrahedron,2015,71(2):370-380. |
| APA | 邱海波,钱文建,于顺明,&姚祝军.(2015).Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers.Tetrahedron,71(2),370-380. |
| MLA | 邱海波,et al."Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers".Tetrahedron 71.2(2015):370-380. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。