Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations
文献类型：期刊论文
| 作者 | Li HX(李慧贤)1; Sun Y(孙域)1; Zhang QB(张庆波)1; ZHU YIGUANG1; LI SHUMING1; Li A(李昂)1; Zhang ZS(张长生)1 |
| 刊名 | Org. Lett.
 |
| 出版日期 | 2015 |
| 卷号 | 17期号:2页码:306-309 |
| 其他题名 | Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations |
| 通讯作者 | 张长生 |
| 英文摘要 | Indolosesquiterpene xiamycin A features a pentacyclic core structure. The chemical synthesis of two key precursors, 3-farnesylindole and 3-(epoxyfarnesyl)-indole, allowed elucidation of the enzymatic cascades forming the pentacyclic ring system of xiamycin A by XiaO-catalyzed epoxidation and the membrane protein XiaH-catalyzed terpene cyclization. The substrate flexibility of XiaI, an indole oxygenase for assembly of the central ring, was also demonstrated. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/ol503399b |
| 语种 | 英语 |
| WOS记录号 | WOS:000348331800035 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39487]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 作者单位 | 1.中科院南海海洋研究所 2.中科院上海有机化学研究所, 生命有机化学国家重点实验室 3.德国马堡大学 |
| 推荐引用方式 GB/T 7714 | Li HX,Sun Y,Zhang QB,et al. Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations[J]. Org. Lett.,2015,17(2):306-309. |
| APA | 李慧贤.,孙域.,张庆波.,ZHU YIGUANG.,LI SHUMING.,...&张长生.(2015).Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations.Org. Lett.,17(2),306-309. |
| MLA | 李慧贤,et al."Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations".Org. Lett. 17.2(2015):306-309. |
入库方式： OAI收割
来源：上海有机化学研究所
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