Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2
文献类型：期刊论文
| 作者 | Xie XQ(谢兴巧)1; Li FX(李发祥)1; Wang YY(王圆圆)1; Wang YL(王颖黎)1; Lin ZJ(林志杰)1; Cheng XF(程小芳)1; Liu JP(刘建平)1; Chen CB(陈昌斌)1; Pan LF(潘李锋)1 |
| 刊名 | Autophagy
 |
| 出版日期 | 2015 |
| 卷号 | 11期号:10页码:1775-1789 |
| 其他题名 | 细胞自噬受体蛋白CALCOCO2识别泛素蛋白的分子机制 |
| 通讯作者 | 潘李锋 |
| 英文摘要 | The autophagy receptor CALCOCO2/NDP52 functions as a bridging adaptor and plays an essential role in the selective autophagic degradation of invading pathogens by specifically recognizing ubiquitin-coated intracellular pathogens and subsequently targeting them to the autophagic machinery; thereby it is required for innate immune defense against a range of infectious pathogens in mammals. However, the mechanistic basis underlying CALCOCO2-mediated specific recognition of ubiqutinated pathogens is still unknown. Here, using biochemical and structural analyses, we demonstrated that the cargo-binding region of CALCOCO2 contains a dynamic unconventional zinc finger as well as a C2H2-type zinc-finger, and only the C2H2-type zinc finger specifically recognizes mono-ubiquitin or poly-ubiquitin chains. In addition to elucidating the specific ubiquitin recognition mechanism of CALCOCO2, the structure of the CALCOCO2 C2H2-type zinc finger in complex with mono-ubiquitin also uncovers a unique zinc finger-binding mode for ubiquitin. Our findings provide mechanistic insight into how CALCOCO2 targets ubiquitin-decorated pathogens for autophagic degradations. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1080/15548627.2015.1082025 |
| 语种 | 英语 |
| WOS记录号 | WOS:000363867800006 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39535]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 作者单位 | 1.中科院上海有机化学研究所, 生命有机化学国家重点实验室 2.中科院上海有机化学研究所, 生物与化学交叉研究中心 3.中科院上海上海巴斯德研究所 4.香港科技大学 |
| 推荐引用方式 GB/T 7714 | Xie XQ,Li FX,Wang YY,et al. Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2[J]. Autophagy,2015,11(10):1775-1789. |
| APA | 谢兴巧.,李发祥.,王圆圆.,王颖黎.,林志杰.,...&潘李锋.(2015).Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2.Autophagy,11(10),1775-1789. |
| MLA | 谢兴巧,et al."Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2".Autophagy 11.10(2015):1775-1789. |
入库方式： OAI收割
来源：上海有机化学研究所
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