Stereoselectivity in N-Iminium Ion Cyclization: Development of an Efficient Synthesis of (+/-)-Cephalotaxine
文献类型：期刊论文
| 作者 | Liu H(刘浩)1; Yu J(于静)1; Li XY(李新宇)1; Yan R(严睿)1; Xiao JC(肖吉昌)1; Hong R(洪然)1 |
| 刊名 | Org. Lett.
 |
| 出版日期 | 2015 |
| 卷号 | 17期号:18页码:4444-4447 |
| 其他题名 | 立体选择性亚胺阳离子关环: (+/-)三尖杉碱的高效合成 |
| 通讯作者 | 洪然 |
| 英文摘要 | A stereoselective N-iminium ion cyclization with allylsilane to construct vicinal quaternary tertiary carbon centers was developed for the concise synthesis of (+/-)-cephalotaxine. The current strategy features a TiCl4-promoted cyclization and ring-closure metathesis to furnish the spiro-ring system. The stereochemical outcome in the N-acyliminium ion cyclization was rationalized by the stereoelectronic effect of the Z- or E-allylsilane. Two diastereomers arising from the cyclization were merged into the formal synthesis of (+/-)-cephalotaxine. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/acs.orglett.5b02106 |
| 语种 | 英语 |
| WOS记录号 | WOS:000361867800012 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39805]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 作者单位 | 1.中科院上海有机化学研究所, 天然产物有机合成化学重点实验室 2.中科院上海有机化学研究所, 有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu H,Yu J,Li XY,et al. Stereoselectivity in N-Iminium Ion Cyclization: Development of an Efficient Synthesis of (+/-)-Cephalotaxine[J]. Org. Lett.,2015,17(18):4444-4447. |
| APA | 刘浩,于静,李新宇,严睿,肖吉昌,&洪然.(2015).Stereoselectivity in N-Iminium Ion Cyclization: Development of an Efficient Synthesis of (+/-)-Cephalotaxine.Org. Lett.,17(18),4444-4447. |
| MLA | 刘浩,et al."Stereoselectivity in N-Iminium Ion Cyclization: Development of an Efficient Synthesis of (+/-)-Cephalotaxine".Org. Lett. 17.18(2015):4444-4447. |
入库方式： OAI收割
来源：上海有机化学研究所
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