Nitroso-ene cyclization enabled access to 1-azaspiro[4.4]nonane and its application in a modular synthesis toward (+/-)-cephalotaxine
文献类型：期刊论文
| 作者 | Huang SH(黄莎华)1; Tian XC(田学超)1; Mi XW(米贤伟)1; Wang Y(王燕)1; Hong R(洪然)1 |
| 刊名 | Tetrahedron Lett.
 |
| 出版日期 | 2015 |
| 卷号 | 56期号:48页码:6656-6658 |
| 其他题名 | 亚硝基-烯氢反应构建1-氮杂螺环[4.4]壬烷以及其在(±)-三尖杉碱模型反应中的应用 |
| 通讯作者 | 黄莎华 ; 王燕 |
| 英文摘要 | In this communication, a nitroso-ene cyclization was devised to rapidly construct 1-azaspiro[4.4]nonane, a key structural motif which was further implemented into the modular synthesis of (+/-)-cephalotaxine (6). The whole synthesis route to access the key intermediate 7 involves eight steps from a commercially available 1,2-epoxycyclopentane (12) and five purifications on silica gel column. The direct nitroso-ene reaction to 1-azabicyclo[4.4]non-2-one paves a way to a future development of the practical synthesis of cephalotaxus alkaloids. (C) 2015 Published by Elsevier Ltd. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tetlet.2015.10.002 |
| 语种 | 英语 |
| WOS记录号 | WOS:000365060400002 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39813]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 作者单位 | 1.上海应用技术学院 2.中科院上海有机化学研究所, 天然产物有机合成化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Huang SH,Tian XC,Mi XW,et al. Nitroso-ene cyclization enabled access to 1-azaspiro[4.4]nonane and its application in a modular synthesis toward (+/-)-cephalotaxine[J]. Tetrahedron Lett.,2015,56(48):6656-6658. |
| APA | 黄莎华,田学超,米贤伟,王燕,&洪然.(2015).Nitroso-ene cyclization enabled access to 1-azaspiro[4.4]nonane and its application in a modular synthesis toward (+/-)-cephalotaxine.Tetrahedron Lett.,56(48),6656-6658. |
| MLA | 黄莎华,et al."Nitroso-ene cyclization enabled access to 1-azaspiro[4.4]nonane and its application in a modular synthesis toward (+/-)-cephalotaxine".Tetrahedron Lett. 56.48(2015):6656-6658. |
入库方式： OAI收割
来源：上海有机化学研究所
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