Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts
文献类型：期刊论文
| 作者 | Wu J(吴江); Gu Y(古阳); Leng XB(冷雪冰); Shen QL(沈其龙) |
| 刊名 | Angew. Chem.-Int. Edit.
 |
| 出版日期 | 2015 |
| 卷号 | 54期号:26页码:7648-7652 |
| 其他题名 | Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts |
| 通讯作者 | 沈其龙 |
| 英文摘要 | An efficient copper-promoted difluoromethylthiolation of aryl and heteroaryl diazonium salts is described. The reaction is conducted under mild reaction conditions and various functional groups were compatible. In addition, reactions of heteroaryl diazonium salts such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl, and pyrazolyl diazonium salts occurred smoothly to afford the medicinally important difluoromethylthiolated heteroarenes. Furthermore, a more practical one-pot direct diazotization and difluoromethylthiolation protocol was developed, and it converts the aniline derivatives into difluoromethylthiolated arenes. The utility of the method is demonstrated by difluoromethylthiolation of a number of natural products and drug molecules. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/anie.201502113 |
| 语种 | 英语 |
| WOS记录号 | WOS:000356390900035 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39727]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 作者单位 | 中科院上海有机化学研究所, 有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Wu J,Gu Y,Leng XB,et al. Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts[J]. Angew. Chem.-Int. Edit.,2015,54(26):7648-7652. |
| APA | 吴江,古阳,冷雪冰,&沈其龙.(2015).Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts.Angew. Chem.-Int. Edit.,54(26),7648-7652. |
| MLA | 吴江,et al."Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts".Angew. Chem.-Int. Edit. 54.26(2015):7648-7652. |
入库方式： OAI收割
来源：上海有机化学研究所
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