Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides
文献类型：期刊论文
| 作者 | Feng Z(冯璋); Min QQ(闵巧桥); Zhang XG(张新刚) |
| 刊名 | Synthesis
 |
| 出版日期 | 2015 |
| 卷号 | 47期号:19页码:2912-2923 |
| 其他题名 | 钯催化下烯烃与二氟烷基的Heck反应 |
| 通讯作者 | 张新刚 |
| 英文摘要 | An efficient method for the synthesis of difluoroalkylated alkenes through palladium-catalyzed Heck-type reaction with functionalized difluoromethyl bromides has been developed. The advantages of this protocol are its synthetic simplicity, excellent functional group compatibility, and efficient late-stage difluoroalkylation of biologically relevant molecules, thus paving a new way for application in drug discovery and development. Mechanistic studies revealed that the free difluoroalkyl radicals, initiated by a [Pd(0)L-n] via a single-electron-transfer (SET) pathway, were involved in the Heck-type catalytic cycle. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1055/s-0035-1560457 |
| 语种 | 英语 |
| WOS记录号 | WOS:000362568400007 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39747]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 作者单位 | 中科院上海有机化学研究所, 有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Feng Z,Min QQ,Zhang XG. Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides[J]. Synthesis,2015,47(19):2912-2923. |
| APA | 冯璋,闵巧桥,&张新刚.(2015).Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides.Synthesis,47(19),2912-2923. |
| MLA | 冯璋,et al."Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides".Synthesis 47.19(2015):2912-2923. |
入库方式： OAI收割
来源：上海有机化学研究所
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