Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers
文献类型：期刊论文
| 作者 | Liu JB(刘建波)1; Chen C(陈超)1; Chu LL(储玲玲)1; Chen ZH(陈增浩)1; Xu XH(徐修华)1; Qing FL(卿凤翎)1 |
| 刊名 | Angew. Chem.-Int. Edit.
 |
| 出版日期 | 2015 |
| 卷号 | 54期号:40页码:11839-11842 |
| 其他题名 | 银参与酚的氧化三氟甲基化反应: 芳基三氟甲基醚的直接合成 |
| 通讯作者 | 卿凤翎 |
| 英文摘要 | Aryl trifluoromethyl ethers (ArOCF3) are prevalent in pharmaceuticals, agrochemicals, and materials. However, methods for the general and efficient synthesis of these compounds are extremely underdeveloped and limited. Herein, we describe a highly efficient and general procedure for the direct O-trifluoromethylation of unprotected phenols through a silver-mediated cross-coupling reaction using CF3SiMe3 as the CF3 source and exogenous oxidants. This novel oxidative trifluoromethylation provides access to a wide range of aryl trifluoromethyl ethers from simple phenols. The mild process was also applied to the late-stage trifluoromethylation of a medicinally relevant compound. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/anie.201506329 |
| 语种 | 英语 |
| WOS记录号 | WOS:000363394800045 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39750]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 作者单位 | 1.中科院上海有机化学研究所, 有机氟化学重点实验室 2.东华大学 |
| 推荐引用方式 GB/T 7714 | Liu JB,Chen C,Chu LL,et al. Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers[J]. Angew. Chem.-Int. Edit.,2015,54(40):11839-11842. |
| APA | 刘建波,陈超,储玲玲,陈增浩,徐修华,&卿凤翎.(2015).Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers.Angew. Chem.-Int. Edit.,54(40),11839-11842. |
| MLA | 刘建波,et al."Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers".Angew. Chem.-Int. Edit. 54.40(2015):11839-11842. |
入库方式： OAI收割
来源：上海有机化学研究所
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