Synthesis of diaryldifluoromethanes by Pd-catalyzed difluoroalkylation of arylboronic acids
文献类型：期刊论文
| 作者 | Gu JW(顾继伟); Guo WH(郭文豪); Zhang XG(张新刚) |
| 刊名 | Org. Chem. Front.
 |
| 出版日期 | 2015 |
| 卷号 | 2期号:1页码:38-41 |
| 其他题名 | 通过钯催化芳基硼酸的二氟烷基化合成二芳基二氟甲烷 |
| 通讯作者 | 张新刚 |
| 英文摘要 | Diaryldifluoromethanes constitute a distinct class of fluorinated compounds in medicinal chemistry. But only limited methods to access this structural motif have been reported. Herein, we demonstrate the first example of Pd-catalyzed aryldifluoromethylation of arylboronic acids with readily available aryldifluoromethyl bromides. Because of its high efficiency, excellent functional group compatibility, and mild reaction conditions, this protocol provides a facile access to diaryldifluoromethanes. Preliminary mechanistic studies revealed that a Pd(0) L-n-initiated single electron transfer (SET) pathway is involved in the catalytic cycle. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1039/c4qo00246f |
| 语种 | 英语 |
| WOS记录号 | WOS:000364442500007 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39755]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 作者单位 | 中科院上海有机化学研究所, 有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Gu JW,Guo WH,Zhang XG. Synthesis of diaryldifluoromethanes by Pd-catalyzed difluoroalkylation of arylboronic acids[J]. Org. Chem. Front.,2015,2(1):38-41. |
| APA | 顾继伟,郭文豪,&张新刚.(2015).Synthesis of diaryldifluoromethanes by Pd-catalyzed difluoroalkylation of arylboronic acids.Org. Chem. Front.,2(1),38-41. |
| MLA | 顾继伟,et al."Synthesis of diaryldifluoromethanes by Pd-catalyzed difluoroalkylation of arylboronic acids".Org. Chem. Front. 2.1(2015):38-41. |
入库方式： OAI收割
来源：上海有机化学研究所
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