Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes
文献类型：期刊论文
| 作者 | He ZT(何智涛); Tang XQ(唐小齐); Xie LB(谢立波); Cheng M(成沔); Tian P(田平); Lin GQ(林国强) |
| 刊名 | Angew. Chem.-Int. Edit.
 |
| 出版日期 | 2015 |
| 卷号 | 54期号:49页码:14815-14818 |
| 其他题名 | 高效构建双环[4.3.0]壬烷: 铜催化的含有联烯结构的环己二烯酮的不对称硅化环化反应 |
| 通讯作者 | 林国强 |
| 英文摘要 | The creation of three consecutive chiral carbon centers in one step is achieved using Cu-catalyzed asymmetric silylative cyclization of cyclohexadienone-tethered allenes. Through regioselective beta-silylation of the allene and subsequent enantioselective 1,4-addition to cyclohexadienone, this tandem reaction could afford cis-hydrobenzofuran, cis-hydroindole, and cis-hydroindene frameworks with excellent yields (80-98%) and enantioselectivities (94-98% ee) bearing vinylsilane and enone substructures. Meanwhile, this mild transformation is generally compatible with a wide range of functional groups, which allows further conversion of the bicyclic products to bridged and tricyclic ring structures. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/anie.201508125 |
| 语种 | 英语 |
| WOS记录号 | WOS:000367723400037 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39770]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 作者单位 | 中科院上海有机化学研究所, 天然产物有机合成化学重点实验室 |
| 推荐引用方式 GB/T 7714 | He ZT,Tang XQ,Xie LB,et al. Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes[J]. Angew. Chem.-Int. Edit.,2015,54(49):14815-14818. |
| APA | 何智涛,唐小齐,谢立波,成沔,田平,&林国强.(2015).Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes.Angew. Chem.-Int. Edit.,54(49),14815-14818. |
| MLA | 何智涛,et al."Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes".Angew. Chem.-Int. Edit. 54.49(2015):14815-14818. |
入库方式： OAI收割
来源：上海有机化学研究所
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